Maji, S.K.

Dr. Samir K. Maji
Professor

Phone: +(91-22) 2576 7774
E-mail: samirmaji [at] iitb.ac.in
Location: Room No. 305, BSBE Building
Lab web page

Research Interest

  • Studying mechanisms of protein mis-folding, aggregation and amyloid formation associated with human neurodegenerative diseases such as Alzheimer’s, Parkinson’s and Prions.
  • p53 amyloids in cancer
  • Understanding the role of amyloid in secretory granules biogenesis in mammalian organs.
  • De novo design of functional amyloids for drug delivery and tissue engineering

Academic Background

  • 1996: B.Sc (Chemistry) University of Calcutta, Kolkata, WB
  • 1998: M.Sc (Chemistry) University of Calcutta, Kolkata, WB
  • 2002: Ph.D. (Peptide Chemistry) Indian association for The Cultivation of Science, Jadavpur, Kolkata, WB

Teaching (current)

Biological Thermodynamics and Kinetics, Biophysics Laboratory, Biophysical Chemistry, Topics in Biotechnology

Professional Experience

  • Harvard Medical School and BWH , USA
  • University of California, Los Angeles, USA
  • Salk Institute, La jolla, USA
  • ETH Zurich, Switzerland

Awards/Honors

  • Fellow of Royal Society of Chemistry (FRSC) (2021)
  • Elected as Fellow of National Academy of Science, India (FNASc) (2020).
  • IIT Bombay Excellence in Teaching Award(2020)
  • Tata Innovation Fellowship by the Department of Biotechnology (DBT) (2020).
  • NASI-Reliance Platinum Jubilee Awardfor Application Oriented Innovation in Biological Sciences (2019).
  • Editorial Board Memberof The Journal of Biological Chemistry (2018).
  • National Bioscience Award for Career Development, by the Department of Biotechnology 2016
  • IIT Bombay Research Publication Award for the year 2016
  • Young researcher award, Lady Tata memorial Trust 2013

Selected Publications

  • S Ray and SK Maji (2020), Predictable phase-separated proteins. Nature Chemistry, 12:787–789 (invited commentary article) 
  • S Ray, N Singh, R Kumar, K Patel, S Pandey, D Datta, J Mahato, R Panigrahi, A Navalkar, S Mehra, L Gadhe, D Chatterjee, AS Sawner, S Maiti, S Bhatia, J Gerez, A Chowdhury, A Kumar, R Padinhateeri, R Riek, G Krishnamoorthy and SK Maji, (2020), α‐Synuclein aggregation nucleates through liquid-liquid phase separation. Nature Chemistry , 12:705–716.
  • A Navalkar, S Ghosh, S Pandey, A Paul, D Datta and SK Maji (2019), Prion-like p53 amyloids in cancer. Biochemistry, 59 (2):146–155.
  • S Mehra, D Ghosh, R Kumar, M Mondal, LG Gadhe, S Das, A Anoop, NN Jha, RS Jacob, D Chatterjee, S Ray, N Singh, A Kumar, and SK Maji (2018), Glycosaminoglycans have variable effects on α-synuclein aggregation and differentially affect the activities of the resulting amyloid fibrils. Journal of Biological Chemistry, 293(34): 12975-12991.
  • R Kumar, S Das, GM Mohite, SK Rout, S Halder, NN Jha, S Ray, S Mehra, V Agarwal and SK Maji (2018), Cytotoxic oligomers and fibrils trapped in a gel-like state of α-synuclein assemblies. Angewandte Chemie International Edition, 7(19), 5262-5266.
  • S Ghosh, S Salot, S Sengupta, A Navalkar, D Ghosh, RS Jacob, S Das, R Kumar, NN Jha, S Sahay, S Mehra, GM Mohite, SK Ghosh, M Kombrabail, G Krishnamoorthy, P Chaudhari, and SK Maji (2017), p53 amyloid formation leading to its loss of function: Implications in cancer pathogenesis.  Cell Death and Differentiation, 24:1784–1798.
  • S Das, K Zhou, D Ghosh, NN Jha, PK Singh, RS Jacob, C Bernard, D Finkelstein, J Forsythe and SK Maji (2016), Implantable Amyloid Hydrogels for Promoting Stem Cell Differentiation to Neurons. NPG Asia Materials, 8:e304; DOI:10.1038/am.2016.116.
  • RS Jacob, E George, PK Singh, S Salot, A Anoop, NN Jha, S Sen and SK Maji (2016), Cell Adhesion on Amyloid Fibrils Lacking Integrin Recognition Motif. Journal of Biological Chemistry, 4,291(10):5278-5298.
  • RS Jacob; D Ghosh; PK Singh; SK Basu; NN Jha; S Das; PK Sukul; S Patil; S Sathaye; A Kumar; A Chowdhury; S Malik; S Sen; SK Maji (2015). Self-Healing Hydrogels Composed of Amyloid Nano Fibrils for Cell Culture and Stem Cell Differentiation. Biomaterials, 54:97-105
  • S Sahay, D Ghosh, S Dwivedi S, A Anoop, GM Mohite, M Kombrabail, G Krishnamoorthy, SK Maji (2015), Familial Parkinson’s disease associated mutations alter the site-specific microenvironment and dynamics of α-Synuclein. Journal Biological Chemistry, 290(12):7804-22
  • SK Maji, MH. Perrin, MR Sawaya, S Jessberger, K Vadodaria, RA Rissman, PS Singru, KPR Nilsson, R Simon, D Schubert, D Eisenberg, J Rivier, P Sawchenko, W Vale and R Riek (2009) Functional Amyloids as Natural Storage of Peptide Hormones in Pituitary Secretory Granules, Science 325: 328-332.
  • SK Maji, D. Schubert, JE Rivier, C Rivier, S Lee and R Riek (2008) Amyloid as depot for the formulation of long-acting drugs (2008), PLoS Biology, 6(2):e17.