Kunwar, A.
Dr. Ambarish Kunwar
Professor
Phone: +(91-22) 2576 7799
E-mail: akunwar [at] iitb.ac.in
Location: Lab No. 204, BSBE Building
Lab web page
Research Interest
Our lab works in the area of biophysics and computational biology.
We use Monte-Carlo Simulations to study
- Transport and force generation by motor Proteins
- Microtubule dynamics
We use Molecular Dynamics simulations to study
- Interaction of potential anti-cancer drugs with microtubules
- Interaction of microtubule associated proteins (MAPs) with microtubules
- Effect of pathogenic variation on proteins involved in Endocrine diseases
We also work on development of various robotic and non-robotic disinfection /sterilization devices based on
- Germicidal UVC radiation
- Far-UVC radiation
- Ozone
Academic Background
- B.Sc. (Honours): Banaras Hindu University, 1999
- M.Sc. (Physics): Banaras Hindu University, 2001
- Ph.D.: Indian Institute of Technology Kanpur, 2006
Professional Experience
- Professor: Indian Institute of Technology Bombay, 2022
- Associate Professor: Indian Institute of Technology Bombay, 2016-2022
- Assistant Professor : Indian Institute of Technology Bombay, 2012-2016
- Assistant Professor : Indian Institute of Technology Gandhinagar, 2011-2012
- Postdoctoral Scholar : Department of Neurobiology, Physiology & Behavior, University of California Davis, 2008-2011
- Postdoctoral Scholar : Department of Developmental and Cell Biology, University of California Irvine, 2006-2008
Awards / Honors
- Innovative Young Biotechnologist Award for the year 2012 (IYBA 2012), Department of Biotechnology, India
- Young Faculty Award, IIT Bombay
- Excellence-in-Research Fellowship, IIT Gandhinagar
Selected Recent Publications
- Khushnandan Rai, Bajarang Vasant Kumbhar, Dulal Panda and Ambarish Kunwar. Computational study of interactions of anti-cancer drug eribulin with human tubulin isotypes. Phys. Chem. Chem. Phys., 24, 16694 (2022)
- Saumya Yadav and Ambarish Kunwar. Sliding of motor tails on cargo surface due to drift and diffusion affects their team arrangement and collective transport. Physical Biology. 20 016002 (2022)
- Saumya Yadav and Ambarish Kunwar, Temperature-Dependent Activity of Motor Proteins: Energetics and Their Implications for Collective Behavior, Frontiers in cell and developmental biology vol. 9 610899. 26 Feb. 2021, doi:10.3389/fcell.2021.610899
- Vishwambhar Bhandare, Bajarang Vasant Kumbhar and Ambarish Kunwar, Differential binding affinity of tau repeat region R2 with neuronal specific β-tubulin isotypes, Scientific Reports 9, 10795 (2019)
- Carlos M. Guardia, Raffaella De Pace, Aritra Sen, Amra Saric, Michal Jarnik, David A. Kolin, Ambarish Kunwar, Juan S. Bonifacino, Reversible association with motor proteins (RAMP): A streptavidin-based method to manipulate organelle positioning, PLoS Biology 17(5): e3000279 (2019)
- Bajarang Vasant Kumbhar, Vishwambhar Bhandare, Dulal Panda and Ambarish Kunwar, Delineating the Interaction of Combretastatin A-4 with αβ tubulin Isotypes present in Drug Resistant Human Lung Carcinoma using a Molecular Modeling Approach, Journal of Biomolecular Structure and Dynamics. DOI: 10.1080/07391102.2019.1577174 (2019)
- Bajarang Vasant Kumbhar, Dulal Panda and Ambarish Kunwar, Interaction of microtubule depolymerizing agent indanocine with different human αβ tubulin isotypes, PLoS ONE 13(3): e0194934 (2018)
- Anjneya Takshak, Tanushree Roy, Parag Tandaiya and Ambarish Kunwar, Effect of Fuel Concentration and Force on Collective Transport by a Team of Dynein Motors, Protein Science, Vol. 26, 186–197 (2017) 2015 Journal Impact Factor = 3.039
- Weili Hong, Anjneya Takshak, Olaolu Osunbayo, Ambarish Kunwar and Michael Vershinin, The Effect of Temperature on Microtubule-Based Transport by Cytoplasmic Dynein and Kinesin-1 Motors, Biophysical Journal, Vol. 111, 1287 (2016)
- Bajarang Vasant Kumbhar, Anubhaw Borogaon, Dulal Panda and Ambarish Kunwar, Exploring the Origin of Differential Binding Affinities of Human Tubulin Isotypes αβII, αβIII and αβIV for DAMA-colchicine using Homology Modelling, Molecular Docking and Molecular Dynamics Simulation, PLoS ONE 11(5): e0156048 (2016)
- Anjneya Takshak and Ambarish Kunwar, Importance of anisotropy in detachment rates for force production and cargo transport by a team of motor proteins, Protein Science, Vol. 25, 1075 (2016) 2015 Journal Impact Factor = 3.039