Kumar, A.

Dr. Ashutosh Kumar
Associate Professor

Phone: +(91-22) 2576 7762
E-mail: ashutoshk [at] iitb.ac.in
Location: Room No. 606, BSBE Building
Lab web page

Research Interest

  • Structural Biology, Biophysics,Solid and Liquid-state NMR Spectroscopy, Protein-Protein, Protein-lipid and Protein-drug interactions.

Academic Background

  • B. Sc. (Chemistry (Hons.) with Physics and Mathematics) from Faculty of    Science, Banaras Hindu University, Varanasi, India (1996 – 1999)
  • M. Sc. : (Chemistry) from Indian Institute of Technology (IIT) Delhi, New Delhi, India (1999 – 2001)
  • Ph.D. : (Chemistry) from Department of Chemical Sciences,Tata Institute of Fundamental Research (TIFR), Mumbai, India (2001 – 2007)

Teaching (current)

Biophysical Chemistry

Professional Experience

  • 2007 -2010: Post-doctoral Research: Solid-state NMR Group, Department of NMR Based Structural Biology, Max-Planck-Institute for Biophysical Chemistry, Goettingen, Germany.
  • since 2011: Assistant Professor,  Department of Biosciences and Bioengineering, IIT Bombay

Awards and Fellowships

  • Ramalingaswami Fellowship from Department of Biotechnology, Govt. of India. 2011-2015.
  • Marie-Curie Fellowship from European Union under IIF FP7 framework for Post-doctoral Fellowship during 2008-2010.
  • Alexander-von-Humboldt Fellowship for Post-doctoral research. (did not avail).
  • Max-Planck-Fellowship for Post-doctoral research during 2007-2008.

Publications

    • Kumar A, Heise H, Blommers M, Krastel P, Schmitt E, Petersen F,   Mandelkow E, Carlomagno     T, Griesinger C, Baldus M (2010) Interaction of epothilone B (patupilone) with microtubules as detected by   two-dimensional Solid-state NMR. Angw. Chem. Int. Ed. 49 (41), 7504-7.
    • Kim HY, Cho MK, Kumar A, Maier E, Siebenhaar C, Becker S, Fernandez CO, Lashuel HA, Benz R, Lange A, Zweckstetter M. (2009) Structural Properties of Pore-Forming Oligomers of alpha-Synuclein. J. Am. Chem. Soc. 131, 17482-17489.
    • Karpinar DP, Balija MB, Kügler S, Opazo F, Rezaei-Ghaleh N, Wender N, Kim HY, Taschenberger G, Falkenburger BH, Heise H, Kumar A, Riedel D, Fichtner L, Voigt A, Braus GH, Giller K, Becker S, Herzig A, Baldus M, Jäckle H, Eimer S, Schulz JB, Griesinger C, Zweckstetter M. (2009) Pre-fibrillar alpha-synuclein variants with impaired beta-structure increase neurotoxicity in Parkinson’s disease models. EMBO J. 28, 3256-3268.
    • Kumar D, Misra JR, Kumar A, Chugh J, Sharma S, Hosur RV (2009) NMR-derived solution structure of SUMO from Droshophila melonogaster (dsmt3) Proteins. 75, 1046-1050.
    • Heise H, Celej MS, Becker S, Riedel D, Pelah A, Kumar A, Jovin TM, Baldus M (2008) Solid-state NMR reveals structural differences between fibrils of wild-type and disease-related A53T mutant alpha-synuclein. J. Mol. Biol. 380, 444-450.
    • Kumar D, Kumar A, Misra JR, Chugh J, Sharma S, Hosur RV (2008) 1H, 13C, 15N resonance assignment of folded and 8 M urea-denatured state of SUMO from Droshophila melonogaster. Biomol NMR Assign. 2, 13-15.
    • Kumar A, Srivastava S, Hosur RV (2007) NMR Characterisation of the energy landscape of SUMO-1 in the native-state ensemble. J. Mol. Biol. 367, 1480-1493.