Kumar, A.
Dr. Ashutosh Kumar
Professor
Phone: +(91-22) 2576 7762
E-mail: ashutoshk [at] iitb.ac.in
Location: Room No. 606, BSBE Building
Lab web page
Research Interest
- Structural Biology, Biophysics,Solid and Liquid-state NMR Spectroscopy, Protein-Protein, Protein-lipid and Protein-drug interactions.
Academic Background
- B. Sc. (Chemistry (Hons.) with Physics and Mathematics) from Faculty of Science, Banaras Hindu University, Varanasi, India (1996 – 1999)
- M. Sc. : (Chemistry) from Indian Institute of Technology (IIT) Delhi, New Delhi, India (1999 – 2001)
- Ph.D. : (Chemistry) from Department of Chemical Sciences,Tata Institute of Fundamental Research (TIFR), Mumbai, India (2001 – 2007)
Teaching (current)
Biophysical Chemistry, Drug Discovery and Development, Metabolism and Bioenergetics, Biologics and Biosimilars
Professional Experience
- Professor (2021-): Department of Biosciences and Bioengineering, IIT Bombay
- Associate Professor (2016-2021): Department of Biosciences and Bioengineering, IIT Bombay
- Assistant Professor (2011-2016): Department of Biosciences and Bioengineering, IIT Bombay
- Post-doctoral Research (2007-2010): Solid-state NMR Group, Department of NMR Based Structural Biology, Max-Planck-Institute for Biophysical Chemistry, Goettingen, Germany.
Awards and Fellowships
- Ramalingaswami Fellowship from Department of Biotechnology, Govt. of India. 2011-2015.
- Marie-Curie Fellowship from European Union under IIF FP7 framework for Post-doctoral Fellowship during 2008-2010.
- Alexander-von-Humboldt Fellowship for Post-doctoral research. (did not avail).
- Max-Planck-Fellowship for Post-doctoral research during 2007-2008.
Publications
- Shivangi Shukla, Prakhar Agarwal, Ashutosh Kumar. Disordered regions tune order in chromatin organization and function. Biophysical Chemistry. 281: 106716, 2022.
- Anomitra Dey, Debarghya Mitra, Kavitha Rachineni, Lakshya Raj Khatri, Harshad Paithankar, Navratna Vajpai, Ashutosh Kumar. Mapping of Methyl Epitopes of a Peptide-Drug with Its Receptor by 2D STDD-Methyl TROSY NMR Spectroscopy. ChemBioChem. 23: e202200489. 2022.
- Amrita Bhattacharya, Vaibhav Kumar Shukla, Nitin Kachariya, Preeti, Parveen Sehrawat, Ashutosh Kumar. Disorder in the Human Skp1 Structure is the Key to its Adaptability to Bind Many Different Proteins in the SCF Complex Assembly. Journal of Molecular Biology. 434(21): 167830. 2022.
- Nutan Agadi, Atanu Maity, Akash Kumar Jha, Rajarshi Chakrabarti, Ashutosh Kumar. Distinct mode of membrane interaction and disintegration by diverse class of antimicrobial peptides. Biochimica et Biophysica Acta (BBA) – Biomembranes. 1864(12): 184047. 2022.
- Sehrawat P, Shobhawat R, Kumar A. Catching Nucleosome by Its Decorated Tails Determines Its Functional States. Front Genet. 2022 Jul 14;13:903923. doi: 10.3389/fgene.2022.903923. PMID: 35910215; PMCID: PMC9329655.
- Singh JS, Sajeev T K, Panigrahi R, Cherry P, Panchakshari NA, Shukla VK, Kumar A*, Mishra RK. Implications of critical node-dependent unidirectional cross-talk of Plasmodium SUMO pathway proteins. Biophys J. 2022 Apr 19;121(8):1367-1380. doi: 10.1016/j.bpj.2022.03.022. Epub 2022 Mar 21. PMID: 35331687; PMCID: PMC9072691.
- Shukla, Shivangi, and Ashutosh Kumar. Centromere Chromatin Dynamics at a Glance. Epigenomes 6, no. 4 (2022): 39.doi:10.3390/epigenomes6040039.
- Joshi S, Khatri L K, Kumar A, Rathore S A. Monitoring size and oligomeric-state distribution of therapeutic mAbs by NMR and DLS: Trastuzumab as a case study J Pharm Biomed Anal. 2021.
- Sarkar S, Purusottom N R, Kumar A, Khaneja N. Chirp pulse sequences for broadband π rotation J Magn Reson. 2021
- Pravin N, Kumar R, Tripathi S, Kumar P, Mohite GM, Navalkar A, Panigrahi R, Singh N, Gadhe LG, Manchanda S, Shimozawa M, Nilsson P, Johansson J, Kumar A, Maji SK, Shanmugam M. Benzimidazole‐based Fluorophores for the Detection of Amyloid Fibrils with Higher Sensitivity than Thioflavin‐T J. Neurochem. 2021
- Sharma, K.; Mehra, S.; Sawner, A. S.; Markam, P. S.; Panigrahi, R.; Navalkar, A.; Chatterjee, D.; Kumar, R.; Kadu, P.; Patel, K. Effect of Disease-Associated P123H and V70M Mutations on β-Synuclein Fibrillation ACS Chem. Neurosci. 2020.
- Bishoyi, A. K.; Roham, P. H.; Rachineni, K.; Save, S.; Hazari, M. A.; Sharma, S.; Kumar, A. Human Islet Amyloid Polypeptide (HIAPP)–a Curse in Type II Diabetes Mellitus: Insights from Structure and Toxicity Studies Biol. Chem. 2020
- Ray, S.; Singh, N.; Kumar, R.; Patel, K.; Pandey, S.; Datta, D.; Mahato, J.; Panigrahi, R.; Navalkar, A.; Mehra, S. α-Synuclein Aggregation Nucleates through Liquid–Liquid Phase Separation Nat. Chem. 2020
- Dubey R, Kulkarni SH, Dantu SC, Panigrahi R, Sardesai DM, Malik N, Acharya JD, Chugh J, Sharma S, Kumar A. Myricetin protects pancreatic β-cells from human islet amyloid polypeptide (hIAPP) induced cytotoxicity and restores islet function Biol Chem. 2020
- Bhattacharya, A.; Shukla, V. K.; Hosur, R. V; Kumar, A. Backbone and Side-Chain Resonance Assignments of Centromeric Protein Scm3 from Saccharomyces Cerevisiae Biomol. NMR Assign.2019
- Dubey, R.; Patil, K.; Dantu, S. C.; Sardesai, D. M.; Bhatia, P.; Malik, N.; Acharya, J. D.; Sarkar, S.; Ghosh, S.; Chakrabarti, R. Azadirachtin Inhibits Amyloid Formation, Disaggregates Pre-Formed Fibrils and Protects Pancreatic β-Cells from Human Islet Amyloid Polypeptide/Amylin-Induced Cytotoxicity Biochem. J.2019
- Vasudevan, S. V; Kumar, A. Antimicrobial Peptide ROAD–1 Triggers Phase Change in Local Membrane Environment to Execute Its Activity J. Mol. Model.2019