P R O T E I N N M R L A B

Welcome to Biomolecular NMR Spectroscopy Lab!

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Welcome to Biomolecular NMR Spectroscopy Lab!

Located on the 6th Floor of Biosciences and Bioengineering building, Indian Institute of Technology Bombay, our lab has been instrumental in deciphering the structure and dynamics of proteins involved in crucial pathways such as amyloid formation, centromere assembly, nucleosome dynamics, and the ubiquitin-mediated degradation system. With a focus on NMR spectroscopy along with biophysics and other relevant techniques, we aim to provide mechanistic insights into how the motions, conformational landscapes and interactomes of both folded and intrinsically disordered proteins (or protein assemblies) fine-tune their cellular functions. We also use NMR as a tool to study the cellular metabolome of diseased patients for biomarker identification and targeted therapy. 

Research Area

Nucleosome dynamics

Aberrations in chromosome segregation during cell division lead to developmental defects and cancer.

Regulation of Fates of Cellular Substrates

Skp1-Cullin1-Fbox (SCF) E3 ligase is a multi-protein enzyme complex...

Metabolism And Related Disorders

Amyloid fibrils are highly ordered proteinaceous β-sheet rich insoluble aggregates, which can be formed by....

Our Research Publications on Different Areas

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