Purwar, R

Dr. Rahul Purwar

Associate Professor

Phone: +(91-22) 2576 7737
Fax: +(91-22) 2572 7760
E-mail: purwarrahul[at] iitb.ac.in
Location: Room No. 302, BSBE Building

Lab Webpage

Research Interest

  • Tumor Immunology, Cancer biomarker

Academic Background

  • M.Sc.(Biochemistry): University of Lucknow, India (2000)
  • Ph.D.(Molecular Medicine): Hannover Medical School, Germany (2006)

Professional Experience

  • Postdoc fellow at Hannover Medical School, Germany (2006-2007)
  • Research Fellow at Harvard Medical School, USA  (2007-2012)
  • Scientist II at ImmunoGen Inc. Waltham, MA, USA  (2012-2013)

Awards:
2012 - The Melissa K. Bambino Memorial Award by The Skin Cancer Foundation.
2007 – HBRS Prize (best PhD) by Hannover Biomedical Research School, Hannover, Germany.
2006 – Poster Prize by Global Allergy and Asthma European Network (GA2LEN/EAACI), Hannover, Germany.
2006 – ECARF Award by European Center for Allergy Research Foundation, Germany.
2005 – Travel Award by European Society of Dermatology Research (ESDR), in Tubingen, Germany.
2005 – Travel Award by EAACI in Davos, Switzerland.
2001 – Research Fellowship by CSIR/UGC, India.


Recent Selected Publications

  • Mogha P, Srivastava A, Kumar S, Das S, Kureel S, Dwivedi A, Karulkar A, Jain N, Sawant A, Nayak C, Majumder A, Purwar R. Hydrogel scaffold with substrate elasticity mimicking physiological-niche promotes proliferation of functional keratinocytes. RSC advance 2019 (in press)
  • Das S, Srinivasan S, Srivastava A, Kumar S, Das G, Das S, Dwivedi A, Karulkar A, Makkad K, Bilala R, Gupta A, Sawant A, Nayak C, Tayalia P, Purwar R. Differential Influence of IL-9 and IL-17 on Actin Cytoskeleton Regulates the Migration Potential of Human Keratinocytes. The Journal of Immunology. 2019 Feb 13. doi: 10.4049/jimmunol.1800823. 
  • Dwivedi A, Karulkar A, Ghosh S, Rafiq A, Purwar R. Lymphocytes in Cellular Therapy: Functional Regulation of CAR T Cells. Frontiers in Immunology. 2019 Jan 18;9:3180. PubMed PMID: 30713539.
  • Srinivasan S, Ashok V, Mohanty S, Das A, Das S, Kumar S, Sen S, Purwar R. Blockade of Rho-associated protein kinase (ROCK) inhibits the contractility and invasion potential of cancer stem like cells. Oncotarget. 2017 Mar 28;8(13):21418-21428. This work was highlighted in The Hindu on 25th March 2017: Title “IIT Bombay researchers find a novel target for blocking cancer metastasis”.
  • Dwivedi A, Kumar S, Purwar R. B16 Lung Melanoma Model to Study the Role of Th9 Cells in Cancer. Methods Molecular Biology. 2017;1585:217-222. doi:10.1007/978-1-4939-6877-0_17. PubMed PMID: 28477199.
  • Purwar R, Schlapbach C,Xiao S, Kang HS, Elyaman W, Jetten AM, Khoury S, Fuhlbrigge RC, Kuchroo VK, Clark RA,Kupper TS: Robust tumor immunity to melanoma is mediated by IL‐9 producing T cells. Nat Med. 2012 Aug;18(8):1248-53 This work is appeared on numerous media websites around the globe including Fox news, NPR, Wall Street Journal, Zee news, Times of India, and The Hindu etc.
  • Purwar R*, Bäumer W, Niebuhr M, Tschernig T, Kietzmann M, Werfel T. A protective role of complement component 3 in T cell‐mediated skin inflammation. Exp Dermatol. 2011 Sep;20(9):709-14. *Corresponding author.
  • Purwar R, Campbell J, Murphy G, Richards WG, Clark RA, Kupper TS. Resident memory T cells  (T(RM)) are abundant in human lung: diversity, function, and antigen specificity. PLoS One. 2011 Jan 26;6(1):e16245.
  • Purwar R*, Langer K, Werfel T. Polymorphisms within the C3 gene are associated with specific IgE levels to common allergens and super antigens among atopic dermatitis patients. Exp Dermatol. 2009 Jan;18(1):30-4. *Corresponding author.
  • Gschwandtner M, Purwar R, Wittmann M, Bäumer W, Kietzmann M, Werfel T, Gutzmer R. Histamine upregulates keratinocyte MMP‐9 production via the histamine H1 receptor. J Invest Dermatol. 2008 Dec;128(12):2783-91.
Editorial Activities
  • Ad hoc reviewer: 1) Journal of Immunology, 2) Pediatric dermatology, 3) Journal of Investigative dermatology, 4) International Archives of Allergy & Immunology, 5) Dermatology.