Tayalia, P.

Dr. Prakriti Tayalia
Professor

Phone: +(91-22) 2576 7797
E-mail: prakriti [at] iitb.ac.in
Location: Room No. 602, BSBE Building
Lab web page

Two postdoctoral fellow positions are available in the Cell and Tissue Engineering Lab, located in the Department of Biosciences and Bioengineering, IIT Bombay.

Please visit https://www.bio.iitb.ac.in/~prakriti/ for more information on our lab and research group.
Eligibility: Ph.D. in Biomaterials or Tissue engineering or Nanotechnology or Immunology or Molecular/Cellular Biology.
Deadline: 9th April 2024

Research Interest

  • Our lab has progressively been developing various kinds of material based systems for replicating and understanding in vivo physiological phenomena. With that aim, we are working with three-dimensional (3D) cell culture platforms both for delivery of bioactive molecules as well as recruitment or culture of cells, which can broadly be used for the following applications.
    (1)  Material-based gene delivery: We have an in house expertise of making lentiviral particles for different kinds of genetic modification of cells. We have tried a variety of plasmids and have used different material platforms for delivery of these particles to cells in vitro as well as in vivo. We can transduce different cells using various direct or material based approaches to manipulate cells ex vivo or allow in situ (or in vivo) genetic modification of cells respectively. We are using this platform for immunotherapy and tissue regeneration applications.
    (2)  Porous cryogel scaffolds for 3D cell culture: We have also developed a macroporous hydrogel platform for immunotherapy and spheroid formation.

    1. Immunotherapy: These porous matrices can be loaded with programming factors such as growth factors (or chemokines) and gene delivery vectors, which can be temporally controlled and used to recruit and manipulate host cells upon in vivo implantation. This approach when used in a more cell specific manner with immune cellshas applications in immunotherapy.
    2. Tissue regeneration: Our cryogel matrices are also being developed as an off the shelf degradable macroporous matrix system for full thickness skin regeneration. We plan to develop this system as a substitute for the currently used decellularized cadaveric skin, autografts or other expensive allogeneic cell based or acellular matrices imported in the Indian market.
    3. Spheroid formation: By modulating the composition of these porous matrices, we can grow clusters or spheroids of various kinds of cells. These 3D cell culture platforms can be used (1) to understand underlying cellular mechanisms in normal and pathological conditions and (2) for drug screening applications by exploring cell-cell and cell-ECM interactions, influence of immune cells on tumor cells and vice versa.

    Better understanding of cellular mechanisms in various applications will enable these material based systems developed in our group to be taken forward for some real clinical applications.

Academic Background

  • 2009 : Ph.D. in Applied Physics and Bioengineering, Harvard University, Cambridge, USA
  • 2002 : M.S. in Materials Science & Engineering, University of Delaware, Newark, USA
  • 1999 : B.Tech. in Metallurgical Engineering and Materials Science, Indian Institute of Technology, Bombay, India

Professional Experience

  • Professor (2024 – present): Department of Biosciences and Bioengineering, IIT Bombay, Mumbai, India
  • Associate Professor (2019 – 2024): Department of Biosciences and Bioengineering, IIT Bombay, Mumbai, India
  • Assistant Professor (2011 – 2019): Department of Biosciences and Bioengineering, IIT Bombay, Mumbai, India
  • Postdoctoral Fellow (2009 – 2011): School of Engineering and Applied Sciences, Harvard University, Cambridge, USA

Awards and Honors

  • C1973 Research Excellence Award (in research and innovation) 2024.
  • Outstanding Immunologist Award – Female Category (Indian Immunology Society) 2022.
  • Merck Young Scientist Award for Life Sciences (Merck India) 2021.
  • Department of Biotechnology – Innovative Young Biotechnologist Award (DBT–IYBA) 2013.
  • Young Faculty Award, IIT Bombay.
  • Graduate Student Fellowship, Harvard University, USA
  • Awarded Medal for M.S. research work at the 47th International SAMPE Symposium and Exhibition (ISS&E).
  • Recipient of the prestigious National Talent Search Scholarship awarded by NCERT, New Delhi.
  • Awarded Scholarship and Certificate from Central Board of Secondary Education (CBSE) for being among the top 0.1% in Mathematics and Science in the SSC examination (1993).

Publications

  • Dandia H, Pillai MM, Sharma D, Suvarna M, Dalal N, Madhok A, Ingle A, Chiplunkar SV, Galande A, Tayalia P*. Acellular scaffold-based approach for in situ genetic engineering of host T-cells in solid tumor immunotherapy. Military Medical Research. 2024. 11(1) 3. 10.1186/s40779-023-00503-6.
  • Dhandapani H, Siddiqui A, Karadkar S, Tayalia P*. In vitro 3D spheroid model preserves tumor microenvironment of hot and cold breast cancer subtypes. Advanced Healthcare Materials. 2023. 2300164. 10.1002/adhm.202300164.
  • Saha R, Patkar S, Pillai MM, Tayalia P*. Bilayered skin substitute incorporating rutin nanoparticles for antioxidant, anti-inflammatory, and anti-fibrotic effect. Biomaterials Advances. 2023. 150, 213432. 10.1016/j.bioadv.2023.213432
  • Pillai MM, Saha R, Tayalia P*. Avian eggshell membrane as a material for tissue engineering: A review. J Mater Sci. 2023. 58, 6865–6886. 10.1007/s10853-023-08434-2.
  • Dalal N, Challa R, Thimukonda JJ, Tayalia P*. Gelatin methacryloyl based injectable cryogels with tunable degradability for cell delivery. Macromolecular Bioscience. 2023. 10.1002/mabi.202200562.
  • Sagitha P, Dhandapani H, Tayalia P*. Choline ester based ionic liquid: A multi-functional system to enhance nucleic acid stability, drug solubilization and cell penetration. International Journal of Biological Macromolecules. 2023. 238, 124059.
  • Singh A, Dalal N, Tayalia P*. An interplay of matrix stiffness, dimensionality and adhesivity on cellular behavior. Biomedical Materials. 2023. 18(2) 025010.
  • Pillai MM, Ajesh S, Tayalia P*. Two-photon polymerization based reusable master template to fabricate polymer microneedles for drug delivery. MethodsX. 2023. 102025, ISSN 2215-0161.
  • Mehta A, Desai A, Rudd D, Siddiqui G, Nowell CJ, Tong Z, Creek DJ, Tayalia P, Gandhi PS, Voelcker NH. Bio-Mimicking Brain Vasculature to Investigate the Role of Heterogeneous Shear Stress in Regulating Barrier Integrity. Adv Biol (Weinh).2022. 6(12), e2200152.
  • Saha R, Tayalia P*. Clove Oil incorporated Antibacterial Gelatin-Chitosan Cryogels for Tissue Engineering: An In Vitro Study. ACS Biomater. Sci. Eng. 2022. 8(8), 3557–3567.
  • Singh A, Mirgule J, Pillai MM, Dalal N, Tayalia P*. Particulate leaching improves spheroid formation in PEG and gelatin-based matrices for 3D tumour model. Materials Today Communications. 2022, 31, 103494.
  • Pillai MM, Dandia H, Checker R, Rokade S, Sharma D, Tayalia P*. Novel combination of bioactive agents in bilayered dermal patches provides superior wound healing. Nanomedicine: NBM. 2021, 40, 102495.
  • Saha R, Patkar S, Maniar D, Pillai MM, Tayalia P*. A bilayered skin substitute developed using an eggshell membrane crosslinked gelatin–chitosan cryogel. Biomaterials Science. 2021, 9(23), 7921-7933.
  • Dandia H, Tayalia P*. Immunomodulation via macrophages to fight solid tumor malignancies. FEBS J.2021, 288(3), 799-802.
  • Singh A, Tayalia P*. Three-dimensional cryogel matrix for spheroid formation and anti-cancer drug screening. J Biomed Mater Res.2020, 108(2), 365-376.
  • Dandia H, Makkad K, Tayalia P*. Glycated collagen – a 3D matrix system to study pathological cell behavior.  Sci. 2019, 7(8), 3480-3488.
  • Peter M, Singh A, Mohankumar K, Jeenger R, Joge P, Gatne M, Tayalia P*. Gelatin based matrices as tunable platform to study in vitro and in vivo 3D cell invasion. ACS Appl. Bio Mater. 2019, 2(2), 916–929.
  • Das S, Srinivasan S, Srivastava A, Kumar S, Das G, Das S, Dwivedi A, Karulkar A, Makkad K, Bilala R, Gupta A, Sawant A, Nayak C, Tayalia P, Purwar R. Differential Influence of IL-9 and IL-17 on Actin Cytoskeleton Regulates the Migration Potential of Human Keratinocytes.  Immunol.2019, 202(7), 1949-1961.
  • Kirti S, Patel K, Das S, Shrimali P, Samanta S, Kumar R, Chatterjee D, Ghosh D, Kumar A, Tayalia P, Maji SK. Amyloid Fibrils with Positive Charge Enhance Retroviral Transduction in Mammalian Cells. ACS Biomater. Sci. Eng.2019, 5(1), 126–138.
  • Shrimali P, Peter M, Singh A, Dalal N, Dakave S, Chiplunkar SV, Tayalia P*. Efficient in situ gene delivery via PEG diacrylate matrices.  Sci. 2018, 6, 3241-3250.
  • Peter M, Tayalia P*. An alternative technique for patterning cells on poly(ethylene glycol) diacrylate hydrogels. RSC Adv. 2016, 6, 40878-40885.
  • Madhuri Vinchurkar M, Ashwin M, Joshi A, Singh A, Tayalia P, Rao VR. MEMS aptasensor for label-free detection of cancer cells. 3rd International Conference on Emerging Electronics (ICEE)2016. DOI: 1109/ICEmElec.2016.8074610.

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