Srivastava, R.

Dr. Rohit Srivastava
Professor

Phone: +(91-22) 2576 7746
E-mail: rsrivasta [at] iitb.ac.in
Location: Room No. 505, BSBE Building
Lab web page

Research Interest

  • Fluorescent Biosensors, Nanoengineered Sensors, Controlled Release, Layer-by-Layer Self-Assembly, BioMEMS, Photothermal therapy for breast cancer

Academic Background

  • Ph.D. Biomedical Engineering. Louisiana Tech University, 2005
  • Master of Science in Biomedical Engineering from Louisiana
    Tech University, Ruston, LA, USA
  • B.E. Electronics Engineering. VRCE Nagpur, 1999

Teaching (current)

Signals and Systems, Biomedical Microsystems, Bio-Nanotechnology

Professional Experience

  • Professor – Dec 2015 onwards
  • Associate Professor – Jan 2011 to Nov 2015
  • Assistant Professor since March 2007  to Jan 2011
  • Sr. Lecturer in Bioschool from Sept 2005 – March 2007
  • July 1999 – July 2000: Assistant Systems Engineer at Tata Consultancy Services, SEEPZ, Mumbai

Professional Experience

  • Head of Department
  • Core Committee Member of WRCB, IIT Bombay for last 5 years
  • Core Committee Member for Desai Sethi Centre for Entrepreneurship, IIT Bombay for 3 years
  • Committee Member for Institute Biosafety Committee, IIT Bombay for 3 years
  • Member for Faculty Search Committee for last 6 years at BSBE
  • Convener for Institute and Dept Best Thesis Award Committee for last 6 years at BSBE
  • Member of Department Space Committee for last 6 years at BSBE
  • Member of Department Post Graduate Committee for 3 years at BSBE
  • STAG Member at DBT New Delhi for nanobiotechnology for 3 years
  • TEC Member for DBT Nanobiotechnology, New Delhi for 5 years
  • Chairman of Indo-Russia Committee in DBT New Delhi for 6 years
  • TEC Member of DBT Indo Australia Committee at DBT New Delhi for 6 years
  • TEC Member of all committees at BIRAC, New Delhi for 9 years
  • TEC Member of BioCare, DBT New Delhi for 6 years
  • Task Force member of ICMR Innovation Group for 6 years
  • Task Force member of DST Instrumentation Development Programme for 6 years
  • Task Force member of MHRD Stars Program

Awards

  1. INAE – Abdul Kalam Technology Innovation National Fellowship 2019
  2. NASI – Elected Fellow 2019
  3. Royal Society of Biology – Elected Fellow 2019
  4. Royal Society of Chemistry – Elected Fellow 2019
  5. Shri Om Prakash Bhasin Award for Excellence in Health and Medical Sciences, 2018 – Considered the highest honour in India for Health and Medical Sciences
  6. NASI Reliance Industries Platinum Jubilee Awards 2018
  7. RSC – Elected Member in 2018
  8. DBT National Bioscience Award 2016
  9. Cancer Research Society of India -Best Research Award 2017
  10. DST – Lockheed Martin – Tata Trusts India Innovation Growth Programme (IIGP) 2.0 -University Challenge winners 2017
  11. BIRAC, Shristi and ICMR – Gandhian Young Technological Innovation Award 2017 at Rashtrapati Bhavan Technological Edge Award
  12. Tata Trusts, India Health Fund – Development of therapeutics for MDR-TB
  13. Stars in Global Health, GCC, Canada
  14. Stanford MedTech Award 2016
  15. Lockheed Martin Corporation, US and Department of Science and Technology, Govt of India – Gold Medal 2016
  16. DBT Biotech Product and Process Development and Commercialization Award 2015
  17. IIM Ahmedabad, Shristi and Techpedia -Gandhian Young Technological Innovation Award 2016 at Rashtrapati Bhavan -Technological Edge Award Top 5
  18. IIM Ahmedabad, Shristi and Techpedia – Gandhian Young Technological Innovation Award 2015 at Rashtrapati Bhavan – Technological Edge Award Top 5
  19. Vasvik Award – Award in the area of Biological Sciences and Technology 2013
  20. DBT ABLE BEST 2014 – Biotechnology Entrepreneurship Student Team award 2014
  21. OPPI Award – Young Scientist Award 2014
  22. DBT – Tata Innovation Fellowship
  23. DBT IYBA 2013 , Sr IYBA award from July 2013
  24. HIT Lab – Healthcare Innovation World Cup 2013 -3rd prize overall amongst 150 entries with a cash award of $5000
  25. IIM Ahmedabad, Shristi and Techpedia – Gandhian Young Technological Innovation Award 2013

Publications (2021, 2020)

  1. Singh, B.; Bahadur, R.; Rangara, M.; Gandhi, M. N.; Srivastava, R. Influence of Surface States on the Optical and Cellular Property of Thermally Stable Red Emissive Graphitic Carbon Dots. ACS Appl. Bio Mater. 2021, 4 (5), 4641–4651.
  2. Debnath, S. K.; Srivastava, R.; Debnath, M.; Omri, A. Status of Inhalable Antimicrobial Agents for Lung Infection: Progress and Prospects. Expert Rev. Respir. Med. 2021, 1–20.
  3. Debnath, S. K.; Srivastava, R. Drug Delivery With Carbon-Based Nanomaterials as Versatile Nanocarriers: Progress and Prospects. Front. Nanotechnol. 2021, 3, 15.
  4. Banavath, R.; Srivastava, R.; Bhargava, P. Improved Non-Enzymatic H2O2 Sensors Using Highly Electroactive Cobalt Hexacyanoferrate Nanostructures Prepared through EDTA Chelation Route. Mater. Chem. Phys. 2021, 267, 124593.
  5. Mehta, J. M.; Jain, N. K.; Chauhan, D. S.; Prasad, R.; Kumawat, M. K.; Dhanka, M.; Shanavas, A.; Srivastava, R. Emissive Radiodense Stealth Plasmonic Nanohybrid as X-Ray Contrast and Photo-Ablative Agent of Cancer Cells. Mater. Today Commun. 2021, 27, 102181.
  6. Jejurkar, V. P.; Yashwantrao, G.; Kumar, P.; Neekhra, S.; Maliekal, P. J.; Badani, P.; Srivastava, R.; Saha, S. Design and Development of Axially Chiral Bis(Naphthofuran) Luminogens as Fluorescent Probes for Cell Imaging. Chem. – A Eur. J. 2021, 27 (17), 5470–5482.
  7. Singh, D.; Singh, P.; Pradhan, A.; Srivastava, R.; Sahoo, S. K. Reprogramming Cancer Stem-like Cells with Nanoforskolin Enhances the Efficacy of Paclitaxel in Targeting Breast Cancer. ACS Appl. Bio Mater. 2021, 4, 3670–3685.
  8. Chauhan, D. S.; Dhasmana, A.; Laskar, P.; Prasad, R.; Jain, N. K.; Srivastava, R.; Jaggi, M.; Chauhan, S. C.; Yallapu, M. M. Nanotechnology Synergized Immunoengineering for Cancer. Eur. J. Pharm. Biopharm. 2021, 163, 72–101.
  9. Pradhan, A.; Mishra, S.; Basu, S. M.; Surolia, A.; Giri, J.; Srivastava, R.; Panda, D. Targeted Nanoformulation of C1 Inhibits the Growth of KB Spheroids and Cancer Stem Cell-Enriched MCF-7 Mammospheres. Colloids Surfaces B Biointerfaces 2021, 202, 111702.
  10. Prasad, R.; Jain, N. K.; Yadav, A. S.; Jadhav, M.; Radharani, N. N. V.; Gorain, M.; Kundu, G. C.; Conde, J.; Srivastava, R. Ultrahigh Penetration and Retention of Graphene Quantum Dot Mesoporous Silica Nanohybrids for Image Guided Tumor Regression. ACS Appl. Bio Mater. 2021, 4, 1693–1703.
  11. Singh, B.; Bahadur, R.; Neekhra, S.; Gandhi, M.; Srivastava, R. Hydrothermal-Assisted Synthesis and Stability of Multifunctional Mxene Nanobipyramids: Structural, Chemical, and Optical Evolution. ACS Appl. Mater. Interfaces 2021, 13, 3011–3023.
  12. Khan, A.; Dias, F.; Neekhra, S.; Singh, B.; Srivastava, R. Designing and Immunomodulating Multiresponsive Nanomaterial for Cancer Theranostics. Front. Chem. 2021, 8, 631351.
  13. Mhatre, O.; Reddy, B. P. K.; Patnaik, C.; Chakrabarty, S.; Ingle, A.; De, A.; Srivastava, R. PH-Responsive Delivery of Anti-Metastatic Niclosamide Using Mussel Inspired Polydopamine Nanoparticles. Int. J. Pharm. 2021, 597, 120278.
  14. Kaur, J.; Srivastava, R.; Borse, V. Recent Advances in Point-of-Care Diagnostics for Oral Cancer. Biosens. Bioelectron. 2021, 178, 112995.
  15. Dhanka, M.; Pawar, V.; Chauhan, D. S.; Jain, N. K.; R.S., P.; Shetty, C.; Kumawat, M. K.; Prasad, R.; Srivastava, R. Synthesis and Characterization of an Injectable Microparticles Integrated Hydrogel Composite Biomaterial: In-Vivo Biocompatibility and Inflammatory Arthritis Treatment. Colloids Surfaces B Biointerfaces 2021, 201, 111597.
  16. Thomas, J.; Thangavel, P.; Peh, W. Y.; Jing, J.; Yuvaraj, R.; Cash, S. S.; Chaudhari, R.; Karia, S.; Rathakrishnan, R.; Saini, V.; Shah, N.; Srivastava, R. et al. Automated Adult Epilepsy Diagnostic Tool Based on Interictal Scalp Electroencephalogram Characteristics: A Six-Center Study. Int. J. Neural Syst. 2021, 31, 2050074.
  17. Peh, W. Y.; Thomas, J.; Bagheri, E.; Chaudhari, R.; Karia, S.; Rathakrishnan, R.; Saini, V.; Shah, N.; Srivastava, R.; Tan, Y. L.; et al. Multi-Center Validation Study of Automated Classification of Pathological Slowing in Adult Scalp Electroencephalograms Via Frequency Features. Int. J. Neural Syst. 2021, 2150016.

2020

  1. Jain, N. K.; Dimri, S.; Prasad, R.; Ravichandran, G.; Naidu, V.; De, A.; Srivastava, R. Characteristics of Molecularly Engineered Anticancer Drug Conjugated Organic Nanomicelles for Site-Selective Cancer Cell Rupture and Growth Inhibition of Tumor Spheroids. ACS Appl. Bio Mater. 2020, 3, 7067–7079.
  2. Kadu, P.; Pandey, S.; Neekhra, S.; Kumar, R.; Gadhe, L.; Srivastava, R.; Sastry, M.; Maji, S. K. Machine-Free Polymerase Chain Reaction with Triangular Gold and Silver Nanoparticles. J. Phys. Chem. Lett. 2020, 11, 10489–10496.
  3. Laxman, K.; Reddy, B. P. K.; Mishra, S. K.; Gopal, M. B.; Robinson, A.; De, A.; Srivastava, R.; Ravikanth, M. BF2-Oxasmaragdyrin Nanoparticles: A Non-Toxic, Photostable, Enhanced Non-Radiative Decay-Assisted Efficient Photothermal Cancer Theragnostic Agent. ACS Appl. Mater. Interfaces 2020, 12, 52329–52342.
  4. Laxman, K.; Reddy, B. P. K.; Mishra, S. K.; Robinson, A.; De, A.; Srivastava, R.; Ravikanth, M. Bioinspired Carrier-Free Peptide Conjugated BF2-Oxasmaragdyrin Dye-Based Nano Self-Assemblies: A Photostable NIR Cancer Theragnostic Agent. NPG Asia Mater. 2020, 12, 75.
  5. Chauhan, D. S.; Prasad, R.; Srivastava, R.; Jaggi, M.; Chauhan, S. C.; Yallapu, M. M. Comprehensive Review on Current Interventions, Diagnostics, and Nanotechnology Perspectives against SARS-CoV-2. Bioconjug. Chem. 2020, 31, 2021–2045.
  6. Prasad, R.; Jain, N. K.; Conde, J.; Srivastava, R. Localized Nanotheranostics: Recent Developments in Cancer Nanomedicine. Mater. Today Adv. 2020, 8, 100087.
  7. Thawari, A. G.; Kumar, P.; Srivastava, R.; Rao, C. P. Lysozyme Coated Copper Nanoclusters for Green Fluorescence and Their Utility in Cell Imaging. Mater. Adv. 2020, 1, 1439–1447.
  8. Debnath, S.; Srivastava, R.; Omri, A. Emerging Therapeutics for the Management of COVID 19. Expert Opin. Emerg. Drugs 2020, 1–15.
  9. Laxman, K.; Reddy, B. P. K.; Robinson, A.; Srivastava, R.; Ravikanth, M. Cell-Penetrating Peptide-Conjugated BF2-Oxasmaragdyrins as NIRF Imaging and Photothermal Agents. ChemMedChem 2020, 15, 1–6.
  10. Jejurkar, V. P.; Yashwantrao, G.; Reddy, B. P. K.; Ware, A. P.; Pingale, S. S.; Srivastava, R.; Saha, S. Rationally Designed Furocarbazoles as Multifunctional Aggregation Induced Emissive Luminogens for the Sensing of Trinitrophenol (TNP) and Cell Imaging. ChemPhotoChem 2020, 4, 691–703.
  11. Prabhuraj, R. S.; Mal, A.; Valvi, S. K.; Srivastava, R.; De, A.; Bandyopadhyaya, R. Non-Invasive Preclinical Evaluation of Targeted Nanoparticles for the Delivery of Curcumin in Treating Pancreatic Cancer. ACS Applied Bio Materials 2020, 3, 4643–4654.

Patents Granted

No. Title of the IDF Name of Inventors IPA no.
P1 Polycaprolactone based plasmonic nanoshells and applications thereof Deepak Singh Chauhan Pradeep Kumar Reddy, Mukti Vats, Rajendra Prasad and Rohit Srivastava Granted Indian Patent No: 359768 on 26th February 2021
P2 A method for preparation of ultra-small polymeric nanoparticles Abhijeet Joshi, Maruthi Prasanna, Rashmi Chaudhari and Rohit Srivastava Granted Indian Patent No: 359332 on 24th February 2021
P3 A process for preparation of chitosan based hydrogel Vaishali Pawar and Rohit Srivastava Granted Indian Patent No: 356496 on 22nd January 2021
P4 Drug delivery system Radhika Poojari, Dulal Panda and Rohit Srivastava Granted US Patent No US10888551B2 on 12th January 2021
P5 A composite comprising of doxorubicin-alginate conjugate and non-steroidal anti-inflammatory agent and process for preparation thereof Vaishali Pawar, Vivek Bhaskar Borse and Rohit Srivastava Granted Indian Patent No: 355324 on 05th January 2021
P6 TPGS comprised gold coated poly- (lactic-co-glycolic acid) nanostructures and a process for its preparation Deepak Singh Chauhan, Radhika Poojari, Aravind Kumar Rengan, Asifkhan Shanavas , Abhijit De, Amirali Bakarali Bukhari and Rohit Srivastava Granted Indian Patent No: 354678 on 29th December 2020
P7 Triple action concoction for the complete postoperative management after partial or total knee replacement and process for preparation thereof Vaishali Pawar, Gautam Shetty, Arun Mullaji and Rohit Srivastava Granted Indian Patent No: 354046 on 18th December 2020
P8 A process for synthesis of protein derived branched gold nanostructures Sisini Sasidharan, Dhirendra Bahadur and Rohit Srivastava Granted Indian Patent No: 353933 on 17th December 2020
P9 Fluorescent gold nanorods and method of preparation thereof Rajendra Prasad, Deepak Singh Chauhan, Janhavi Devrukhar, Ramkrishn Gupta and Rohit Srivastava Granted Indian Patent No: 350710 on 3rd November 2020
P10 Hemosealant composition and process for preparation thereof Shruti Mankar, Yasodha kannan Sivasamy and Rohit Srivastava Granted Indian Patent No: 347890 on 28th September 2020
P11 Cyclodextrin capped gold nanostructures and a method of preparation thereof Jaya Raju Lakkakula, Deepika Divakaran Tharayil, Mukeshchand Thakur, Mukesh Kumar Kumawat and Rohit Srivastava Granted Indian Patent No: 346767 on 15th September 2020
P12 Dual therapeutic disintegrable GNR-liposome nanohybrid for plasmonic photothermal cancer theragnostic Deepak Singh Chauhan, Rajendra Prasad, Selvaraj Kaliaperumal and Rohit Srivastava Granted Indian Patent No: 345343 on 27th August 2020
P13 Targeted polymeric nano-complexes as drug delivery system Radhika Poojari, Dulal Panda and Rohit Srivastava Granted Indian Patent No: 344742 on 21st August 2020
P14 Nano-in-Micro formulation as biosensors Rohit Srivastava, Abhijeet Joshi and Rashmi Chaudhary Granted Indian Patent No: 339797 on 29th June 2020
P15 Near infra-red hybrid nanomaterials and graphene oxide for theranostics applications Deepak Singh Chauhan, Mukesh Kumar Kumawat and Rohit Srivastava Granted Indian Patent No: 339645 on 29th June 2020
P16 Pharmaceutically active formulation for healing bone fractures Gautam Shetty, Arun Mullaji, Shreya Agrawal and Rohit Srivastava Granted Indian Patent No: 339582 on 26th June 2020
P17 Zein-gold nanoshells and applications thereof Deepak Singh Chauhan, Arunkumar P., Indulekha S. and Rohit Srivastava Granted Indian Patent No: 319491 on 30th August 2019
P18 Multifunctional polymeric nanocarrier Radhika Poojari, Dulal Panda and Rohit Srivastava Granted Indian Patent No. 317866 on 07th August 2019
P19 Drug delivery system Radhika Poojari, Dulal Panda and Rohit Srivastava Granted Indian Patent No. 315542 on 04th July 2019
P20 Multilayer Nanocomposite Asifkhan Shanavas, Dhirendra Bahadur, Dhirenkumar Sonara, Mohd Aslam and Rohit Srivastava Granted Indian Patent No: 271416 on 19th February 2016
P21 Glucose biosensor system coupled with an anti-inflammatory module and methods for using the same Rohit Srivastava, Rahul Dev Jayant and Ayesha Chaudhary Granted US Patent No US 8916136 B2 on 23rd Dec 2014