Bhaumik, P.

Dr. Prasenjit Bhaumik
Professor

Phone: +(91-22) 2576 7748
E-mail: pbhaumik [at] iitb.ac.in
Location: Room No. 603, BSBE Building
Lab web page

Research Interest

  • Understanding the structure function relationship of enzymes and biological macromolecules. Protein crystallography, Structure based antimalarial drug development, Structural enzymology

Academic Background

  • B.Sc. (Chemistry), 1997: University of Calcutta, Kolkata, India
  • M.Sc. (Biotechnology), 1999: Indian Institute of Technology-Bombay, Mumbai, India
  • Ph.D. (Biochemistry), 2006: University of Oulu, Oulu, Finland

Professional Experience

  • Postdoctoral Fellow (October 2006 – August 2011): National Cancer Institute at Frederick, NIH, USA
  • Assistant Professor: Department of Biosciences and Bioengineering, IIT Bombay
  • Associate Professor: Department of Biosciences and Bioengineering, IIT Bombay

Teaching (current)

Bioinformatics, Protein Crystallography

Awards

  • Excellence in Teaching Award, from IIT Bombay, 2021

  • Ramalingaswami Fellowship from DBT, Govt. of India, 2012

  • Young Faculty Award, from IIT Bombay, 2011

  • Poster prize winner, 40th Mid-Atlantic Protein Crystallography Meeting, USA, 2010
  • Fellows Award for Research Excellence (FARE) award from the NIH, 2009
  • Travel award from American Society of Biochemistry and Molecular Biology (ASBMB), 2009
  • Postdoctoral fellowship from National Cancer Institute, NIH, USA, 2006-2011
  • Ph.D. scholarship from Biocenter Oulu, University of Oulu, Finland, 2000-2006
  • Poster prize winner, Third Annual Conference of the Indian Environmental Association (IEA), 2000
  • National merit scholarship from DBT, Govt. of India, 1997-1999

Selected Publications

  • Kesari, P., Deshmukh, A., Pahelkar, N., Suryawanshi, A. B., Rathore, I., Mishra, V., Dupuis, J. H., Xiao, H., Gustchina, A., Abendroth, J., Labaied, M., Yada, R. Y., Wlodawer, A., Edwards, T. E., Lorimer, D. D. & Bhaumik, P. (2022). Structures of plasmepsin X from P. falciparum reveal a novel inactivation mechanism of the zymogen and molecular basis for binding of inhibitors in mature enzyme. Protein Sci. 31: 882-899.
  • Godsora, B. K. J., Punekar, N. S., & Bhaumik, P. (2022). Molecular insights into the inhibition of glutamate dehydrogenase by the dicarboxylic acid metabolites. Proteins. 90: 810-823.
  • Rathore, I., Mishra, V., & Bhaumik, P. (2021). Advancements in macromolecular crystallography: from past to present. Emerg. Top. Life Sci. 5(1):127-149.
  • Rathore, I., Mishra, V., Patel, C., Xiao, H., Gustchina, A., Wlodawer, A., Yada, R.Y., & Bhaumik, P. (2021). Activation mechanism of plasmepsins, pepsin-like aspartic proteases from Plasmodium, follows a unique trans-activation pathway, FEBS J. 288(2):678-698.
  • Mishra, V., Rathore, I., Arekar, A., Sthanam, L. K., Xiao, H., Kiso, Y., Sen, S., Patankar, S., Gustchina, A., Hidaka. K., Wlodawer, A., Yada, R. Y., & Bhaumik, P. (2018). Deciphering the mechanism of potent peptidomimetic inhibitors targeting Plasmepsins – Biochemical and structural insights. FEBS J. 285, 3077-3096.
  • Prakash, P., Punekar, N. S. & Bhaumik, P. (2018). Structural basis for the catalytic mechanism and α-ketoglutarate cooperativity of glutamate dehydrogenase. J. Biol. Chem. 293, 6241-6258. [Featured on the journal cover]
  • Pandey, S., Modak, A., Phale, P. S. & Bhaumik, P. (2016). High Resolution Structures of Periplasmic Glucose-binding Protein of Pseudomonas putida CSV86 Reveal Structural Basis of Its Substrate Specificity. J. Biol. Chem. 291, 7844-7857.

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