Paul, Debjani

Dr. Debjani Paul

Associate Professor

Phone: +(91-22) 2576 7798
Fax: +(91-22) 2572 7760
E-mail: debjani.paul [at] iitb(dot)ac(dot)in
Location: Room No. 604, BSBE Building
Lab web page

Research Interest

  • Paperfluidics for healthcare applications
  • Microfluidic cell sorting based on size, shape and deformability
  • Mobile microscopy-based diagnostics platform
  • Interaction of cells with their environment (chemotaxis and durotaxis)

Academic Background

  • Integrated PhD (Physics), 2005: Indian Institute of Science, Bangalore, India
Awards
  • Grand Challenges Explorations (Round 14- June 2014) Phase 1 grant from the Bill and Melinda Gates Foundation (through IKP-GCE).
  • Innovative Young Biotechnologist Award (2012) from Department of Biotechnology, Govt. of India.
  • Co-recipient of a Discipline Hopping Grant (2009) from Medical Research Council, UK, (with Drs. Pietro Cicuta and Clare Bryant).
  • College Research Associate (2007-2009), Sidney Sussex College, University of Cambridge.
  • Curie Institute fellowship for foreign researchers (2006).
  • Senior Research Fellowship, Council for Scientific and Industrial Research (2002).

Teaching

  • Medical imaging physics (BB 663)
  • Microfluidics: Physics and Applications (BB 624)
  • Experimental Techniques in Biomedical Engineering (BB 653); course co-ordinator
  • Biosensors and BioMEMS (EE 625); co-instructor with Prof. Ramgopal Rao

Professional Experience

  • Assistant Professor (May 2012 onwards): Department of Biosciences and Bioengineering, IIT Bombay, India.
  • Research Fellow (June 2011 – May 2012): Piramal Healthcare Ltd., Mumbai, India.
  • Research Associate (November 2009 – January 2011): Cavendish Laboratory (Department of Physics), University of Cambridge, Cambridge, United Kingdom.
  • Research Associate (January 2007 – October 2009): Department of Engineering (Electrical Engineering Division), University of Cambridge, Cambridge, United Kingdom.
  • Visiting Researcher (January 2007 – June 2007): MRC Cancer Cell Unit, Hutchison-MRC Research Centre, Cambridge, United Kingdom.
  • Postdoctoral Fellow (March 2005 – December 2006): UMR 168, Physical Chemistry Unit, Curie Institute, Paris, France.


Patents

  • Systems and methods for point-of-care detection and amplification of nucleic acids. D. Paul, P. J. Shetty and A. Jagirdar. Indian patent application 165/Mum/2015 (Jan 16, 2015).
  • Method for fabrication of microlens. S. Mukherji, D. Paul, Bhuvaneshwari K. and A. Jagirdar, Indian patent application 3096/MUM/2014 (Dec 4, 2014).
  • Method for increasing the hydrophobicity of the paper. D. Paul and A. Jagirdar. Indian patent application 1652/MUM/2014 (May 15, 2014).
  • Paper fluidic device for regular monitoring of oral health. D. Paul, A. Jagirdar; P. J. Shetty and R. K. S. Satti. Indian patent application 1653/MUM/2014 (May 15, 2014).
  • Rapid detection of urea in adulterated milk using thread based microfluidic system (US 20140065712 A1). J. Khandare, D. Paul, S. Banerjee, N. Taneja and M. Shidore.
  • Method for improving the bonding properties of microstructured substrates and devices prepared with this method (US 2010/0104480 A1 and PCT/IB2007/055031). J.-L. Viovy, J. Weber, D. Paul, L. Malaquin and S. Miserere.

Selected Publications

  • A paperfluidic device for dental applications using a novel patterning technique, A. Jagirdar, P. Shetty, S. Satti, S. Garg and D. Paul, Analytical Methods, (2015), vol. 7, p. 1293
  • Phagocytosis dynamics depends on target shape, D. Paul, S. Achouri, Y. Z. Yoon, J. Herre, C. E. Bryant and P. Cicuta. Biophysical Journal (2013), vol. 105, p. 1143.
  • Chemical synthesis and sensing in inexpensive thread-based microdevices, S. S.Banerjee, J. Khandare, A. Roychowdhury, N. Taneja, R. Janrao and D. Paul. Sensors and Actuators B: Chemical (2013), vol. 186, p. 439.
  • Transferrin-mediated rapid targeting, isolation and detection of circulating tumor cells by multifunctional magneto-dendritic nanosystem, S. S. Banerjee, A. Jalota-Badhwar, S. D. Satavalekar, S. G. Bhansali, N. D. Aher, R. Mascarenhas, D. Paul, S. Sharma and J. J. Khandare, Advanced Healthcare Materials (2012), vol. 2, p. 800. (Selected as inside cover).
  • Enhancing interactions with colon cancer cells on transferrin-conjugated 3D nanostructured substrate, S. Banerjee#, D. Paul#, A. Jalota-Badhwar, N. Aher, S. Bhansali and J. Khandare, Small (2012), vol. 8, p. 1657.(# equal contributions)
  • A “dry and wet hybrid” lithography technique for multilevel replication templates: Applications to microfluidic neuron culture and two-phase global mixing, D. Paul, L. Saias , J.-C. Pedinotti, M. Chabert , S. Magnifico , A. Pallandre , B. de Lambert, C. Houdayer , B. Brugg , J.-M. Peyrin, J.-L. Viovy, Biomicrofluidics (2011), vol. 5, p. 024102.
  • Label-free sub-picomolar protein detection with field-effect transistors, P. Estrela, D. Paul, Q. Song, L. K. J. Stadler, L. Wang, E. Huq, J. J. Davis, P. Ko Ferrigno, and P. Migliorato, Analytical Chemistry (2010), vol. 82, p. 3531.
  • Fabrication of BioFET linear array for detection of protein interactions, L. Wang, P. Estrela, E.Huq, P. Li, S. Thomas, P. Ko Ferrigno, D. Paul, P. Adkin and P. Migliorato, Microelectronic Engineering (2010), vol. 87, p. 753.
  • Stability of thin film transistors incorporating a zinc oxide or indium zinc oxide channel deposited by a high rate sputtering process, A. J. Flewitt, J.D. Dutson, P. Beecher, D. Paul, S.J. Wakeham, M. E. Vickers, C. Ducati, S. P. Speakman, W. I. Milne and M.J. Thwaites, Semiconductor Science and Technology (2009), vol. 24, p. 085002.
  • Label-free detection of protein interactions with peptide aptamers by open circuit potential measurement, P. Estrela, D. Paul, P. Li, S. D. Keighley, P. Migliorato, S. Laurenson, P. Ko Ferrigno, Electrochimica Acta (2008), vol. 53, p. 6489.
  • Surface immobilised peptide aptamers as probe molecules for protein detection, S. Johnson, D. Evans, S. Laurenson, D. Paul, A.G. Davies, P. Ko Ferrigno and C.Wälti, Analytical Chemistry (2008), vol. 80, p. 978.
  • Lamination-based rapid prototyping of microfluidic devices using flexible thermo plastic substrates, D. Paul, A. Pallandre, S. Miserere, J. Weber, J.-L. Viovy, Electrophoresis (2007), vol. 28, p. 1115.
  • Towards DNA high resolution separation in COC chips, S. Miserere, D. Paul, B. de Lambert, J.-L. Viovy and J.Weber, La Houille Blanche– Revue Internationale de L’eau (2007), vol. 6, p. 58.
  • Dynamic optimization of on-chip polymerase chain reaction by monitoring intracycle fluorescence using fast synchronous detection, S. Mondal, D. Paul, V. Venkataraman, Applied Physics Letters (2007), vol. 90, p. 013902.
  • New monolithic templates and improved protocols for soft lithography and microchip fabrication, A. Pallandre, D. Paul, B. de Lambert, J.-L. Viovy and C. Fütterer, Journal of Physics: Condensed Matter (2006), vol. 18, p. S665.
  • A power-efficient thermocycler for DNA amplification based on induction heating, D. Paul, V. Venkataraman, K. Naga Mohan, H. Sharat Chandra and V. Natarajan, Review of Scientific Instruments (2004), vol. 75, p. 2880.
  • A portable battery-operated chip thermocycler based on induction heating, D. Paul and V. Venkataraman, Sensors and Actuators A (2002), vol. 102, p. 151.