Patankar, S

Dr. Swati Patankar

Professor

Phone: +(91-22) 2576 7773
Fax: +(91-22) 2572 7760
E-mail: patankar [at] iitb.ac.in
Location: Room No. 502, BSBE Building
Lab web page

Research Interest

  • Regulation of gene expression in the malaria parasite Plasmodium falciparum: transcription initiation, translation initiation, splicing
  • Bioinformatics analysis of P. falciparum genome sequence to study regulation of gene expression and acquisition of genetic diversity
  • P. falciparum tubulin as a target for anti-malarial compounds
  • Anti-oxidant networks in P. falciparum

Academic Background

  • 1984-1986 International Baccalaureate
    Armand Hammer United World College, New Mexico, USA
  • 1986-1989 B. Sc. (Honours Programme), Life Sciences/ Biochemistry
    St. Xavier’s College, Mumbai, India
  • 1990-1996 Ph. D., Molecular Microbiology
    Tufts University, Boston, USA
  • 1996 – 2000 Postdoctoral fellow, Immunology & Infectious Diseases
    Harvard School of Public Health, Boston, USA
Teaching
Introduction to Cellular and Molecular Biology, Molecular Biology, Topics in Biotechnology, Genetic Engineering Laboratory

Professional Experience

  • Sept 2000 – June 2002 Group Leader, Genetics, Quest Institute of Life Sciences, Senior Scientist and Lab Head, GeneQuest Laboratory Nicholas Piramal India Ltd., Mumbai, India
  • July – Oct 2002 Visiting scientist, Harvard School of Public Health, Boston, USA
  • Oct 2002 – Feb 2003 Visiting scientist, Advanced Centre for Training, Research and Education in Cancer, Mumbai, India
  • April 2003 – March 2007 Assistant Professor, School of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, India
  • April 2007 – Associate Professor, School of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, India

Memberships

  • 2001-         Life member, Indian Society for Cell Biology
  • 2001-2004: Invited member, The Special Programme for Research and Training in Tropical Diseases (TDR) Working Group on Genomes to Drugs. TDR is described below.
  • 2005-2008: Invited member, TDR Steering Committee on Pathogenesis and Applied Genomics

Publications

  • Panneerselvam, P., Bawankar, P., Kulkarni, S. and Patankar, S. Computational identification of evolutionarily conserved GC-rich elements associated with immunogenic proteins of Plasmodium falciparum. Accepted in Evolutionary Bioinformatics.
  • Patakottu, B.R., Singh, P. K., Malhotra, P., Chauhan, V. S. and Patankar, S. (2011). In vivo analysis of translation initiation sites of P. falciparum. Molecular Biology Reports Epub ahead of print, 2011 Jun 4
  • Kathpal, A., Patakottu, B.R. and Patankar, S. (2011). FORS-D analysis in P. falciparum can differentiate classes of genes under selection. Evolutionary Bioinformatics 7: 21-29
  • Aditya, N.P., Tiyaboonchai W., Patankar, S. and Madhusudhan, B. (2010). Curcuminoids-loaded lipid nanoparticles for antimalarial activity: preparation, physicochemical characterization and in vivo antimalarial activity. Colloids and Surfaces B: Biointerfaces 81(1):263-273
  • Aditya, N.P., Patankar S., Madhusudhan, B., Murthy, R.S.R. and Souto, E.B. (2010). Artemeter-loaded lipid nanoparticles produced by modified-thin film hydration: pharmacokinetics, toxicological and in vivo anti-malarial activity. European Journal of Pharmaceutical Sciences 11;40(5):448-55.
  • Aditya, N. P., Patankar, S. and Madhusudan, B. (2010). Assessment of in vivo antimalarial activity of rifampicin, isoniazide and ethambutol combination therapy. Parasitology Research. 106(6):1481-4
  • Bawankar, P., Shaw, P. J., Sardana, R., Babar P. H. and Patankar, S. (2010). 5′ and 3′ end modifications of spliceosomal RNAs in P. falciparum. Molecular Biology Reports. 37(4): 2125-2133

Collaborations

  • Nanoparticles for anti-malarial therapy
    In collaboration with Prof. B. Madhusudan (Kuvempu University, Karnataka) and Prof. Rinti Banerjee (IIT Bombay), we have developed nanoparticle-based drug delivery systems for anti-malarial drugs that have poor bioavailability. Several papers have been published by Aditya N.P., the PhD student working on the project..
  • Chemically modified antisense oligonucleotides
    In a project with Principal Investigator Pradeepkumar P. I. of the Chemistry Department, IIT Bombay (funded by the Dept. of Biotechnology), chemically modified antisense oligonucleotides are being evaluated as a means to down-regulate the action of siRNAs and miRNAs in human cell lines
  • Proteomics for malaria biomarker discovery
    In a project with Principal Investigator Sanjeeva Srivastava of the Department of Biosciences & Bioengineering, IIT Bombay (funded by the Dept. of Biotechnology), proteomics analyses of samples from malaria patients are being used for discovery of novel biomarkers of the disease

Ph.D. TA International Applicants

We encourage international students to apply for the IIT Bombay institute TA fellowships for our PhD programs. More details about this can be found here: https://www.ir.iitb.ac.in/en/students/scholarship-foreign-phd-students