Patankar, S

Dr. Swati Patankar

Professor

Phone: +(91-22) 2576 7773
Fax: +(91-22) 2572 7760
E-mail: patankar [at] iitb.ac.in
Location: Room No. 502, BSBE Building
Lab web page

Research Interest

  • Regulation of gene expression in the malaria parasite Plasmodium falciparum: transcription initiation, translation initiation, splicing
  • Bioinformatics analysis of P. falciparum genome sequence to study regulation of gene expression and acquisition of genetic diversity
  • P. falciparum tubulin as a target for anti-malarial compounds
  • Anti-oxidant networks in P. falciparum

Academic Background

  • 1984-1986 International Baccalaureate
    Armand Hammer United World College, New Mexico, USA
  • 1986-1989 B. Sc. (Honours Programme), Life Sciences/ Biochemistry
    St. Xavier’s College, Mumbai, India
  • 1990-1996 Ph. D., Molecular Microbiology
    Tufts University, Boston, USA
  • 1996 – 2000 Postdoctoral fellow, Immunology & Infectious Diseases
    Harvard School of Public Health, Boston, USA
Teaching
Introduction to Cellular and Molecular Biology, Molecular Biology, Topics in Biotechnology, Genetic Engineering Laboratory

Professional Experience

  • Sept 2000 – June 2002 Group Leader, Genetics, Quest Institute of Life Sciences, Senior Scientist and Lab Head, GeneQuest Laboratory Nicholas Piramal India Ltd., Mumbai, India
  • July – Oct 2002 Visiting scientist, Harvard School of Public Health, Boston, USA
  • Oct 2002 – Feb 2003 Visiting scientist, Advanced Centre for Training, Research and Education in Cancer, Mumbai, India
  • April 2003 – March 2007 Assistant Professor, School of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, India
  • April 2007 – Associate Professor, School of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, India

Memberships

  • 2001-         Life member, Indian Society for Cell Biology
  • 2001-2004: Invited member, The Special Programme for Research and Training in Tropical Diseases (TDR) Working Group on Genomes to Drugs. TDR is described below.
  • 2005-2008: Invited member, TDR Steering Committee on Pathogenesis and Applied Genomics

Publications

  • Panneerselvam, P., Bawankar, P., Kulkarni, S. and Patankar, S. Computational identification of evolutionarily conserved GC-rich elements associated with immunogenic proteins of Plasmodium falciparum. Accepted in Evolutionary Bioinformatics.
  • Patakottu, B.R., Singh, P. K., Malhotra, P., Chauhan, V. S. and Patankar, S. (2011). In vivo analysis of translation initiation sites of P. falciparum. Molecular Biology Reports Epub ahead of print, 2011 Jun 4
  • Kathpal, A., Patakottu, B.R. and Patankar, S. (2011). FORS-D analysis in P. falciparum can differentiate classes of genes under selection. Evolutionary Bioinformatics 7: 21-29
  • Aditya, N.P., Tiyaboonchai W., Patankar, S. and Madhusudhan, B. (2010). Curcuminoids-loaded lipid nanoparticles for antimalarial activity: preparation, physicochemical characterization and in vivo antimalarial activity. Colloids and Surfaces B: Biointerfaces 81(1):263-273
  • Aditya, N.P., Patankar S., Madhusudhan, B., Murthy, R.S.R. and Souto, E.B. (2010). Artemeter-loaded lipid nanoparticles produced by modified-thin film hydration: pharmacokinetics, toxicological and in vivo anti-malarial activity. European Journal of Pharmaceutical Sciences 11;40(5):448-55.
  • Aditya, N. P., Patankar, S. and Madhusudan, B. (2010). Assessment of in vivo antimalarial activity of rifampicin, isoniazide and ethambutol combination therapy. Parasitology Research. 106(6):1481-4
  • Bawankar, P., Shaw, P. J., Sardana, R., Babar P. H. and Patankar, S. (2010). 5′ and 3′ end modifications of spliceosomal RNAs in P. falciparum. Molecular Biology Reports. 37(4): 2125-2133

Collaborations

  • Nanoparticles for anti-malarial therapy
    In collaboration with Prof. B. Madhusudan (Kuvempu University, Karnataka) and Prof. Rinti Banerjee (IIT Bombay), we have developed nanoparticle-based drug delivery systems for anti-malarial drugs that have poor bioavailability. Several papers have been published by Aditya N.P., the PhD student working on the project..
  • Chemically modified antisense oligonucleotides
    In a project with Principal Investigator Pradeepkumar P. I. of the Chemistry Department, IIT Bombay (funded by the Dept. of Biotechnology), chemically modified antisense oligonucleotides are being evaluated as a means to down-regulate the action of siRNAs and miRNAs in human cell lines
  • Proteomics for malaria biomarker discovery
    In a project with Principal Investigator Sanjeeva Srivastava of the Department of Biosciences & Bioengineering, IIT Bombay (funded by the Dept. of Biotechnology), proteomics analyses of samples from malaria patients are being used for discovery of novel biomarkers of the disease