Welcome to the Proteomics lab, IIT-Bombay. Proteomics is one of the talking points and uprising fields across the globe for solving the intricacies of different clinical complications. It is a relatively newer field than its traditional counterparts, like genomics and transcriptomics. It has garnered a lot of accolades in the last decade and has revolutionized research through the application of high-throughput techniques. The lab majorly researches cancer and infectious diseases.
Cancer Projects –
- Conjunction of integrated multi-omics data with a robust statistical interpretation to understand the chemo-resistance mechanism in triple-negative breast cancer patients that might facilitate efficient treatment towards a new era of personalized medicine.
- Investigates the causes of chemo-radio resistance in cervical cancer through a multi omics-based approach using multiple cell-line-based models to investigate, verify and validate potential biomarkers, driver gene mutations, and target pathways.
- Proteomic evaluation of clinical samples and cell lines to understand the pathophysiology and prognosis of colon adenocarcinomas.
- Understanding molecular mechanisms drive intra- and inter-tumoral heterogeneity in Glioblastomas using the proteo-genomic approach.
- Understanding the pathobiology of Group 3 Medulloblastomas from a proteomic perspective and identifying targets that can have clinical implications in therapy.
- Identification and validation of the potential diagnosis and prognosis biomarkers in oral cancer through multi-omics approaches.
- Identification and validation of the potential diagnosis and prognosis biomarkers of Pituitary cancers using proteomics and metabolomics for translational purposes.
Infectious Diseases –
- Deep proteomic analysis of COVID-19 nasopharyngeal swabs for identification of host prognosis markers.
- Use label-based multiplex proteomics in conjunction with machine learning to explore a panel of proteins to differentiate malaria from dengue, vivax from falciparum and differentiate between the different severe forms of falciparum conditions through plasma samples of the malaria-infected patients and healthy individuals.
Other projects –
- Gene expression investigation of neuroanatomical allied region and brain disorder protein markers in 19 regions and sub-region of the brain to develop a Brain Proteome Database containing curated data of more than 9000 proteins (with isoforms) and around 90000 peptides at www.brainprot.org, to understand the human brain’s complexity.
- Development of proteome map containing proteomic and peptide information for Labeo rohita to study various pathogenesis in fish such as Aeromonas hydrophila.
Our laboratory is well established for high-throughput research with instruments like microarray-reader, Mass Spectrometers (MS), Surface Plasmon Resonance (SPR), Bio-Layer Interferometry (BLI), Ion torrent S5 NGS, and Fourier transform infrared spectroscopy (FTIR). These high-throughput technologies facilitate not only the lab researchers but also many reputed external users (academic and industry) to dig deeper into the problem at hand and help in multi-level validation to gain a confident result.
“India has the potential to tap research opportunities in proteomics and biochips to help understand the biological processes and treat diseases. This is possible even though the country has missed the opportunity to partner in Human Genome Project”Late President Dr. APJ Abdul Kalam
Recent News & Updates:
Heartiest congratulations to Prof. Sanjeeva Srivastava for joining as a Visiting Full Professor, Department of Laboratory Medicine, School of Medicine at University of California, San Francisco.
AugustCongratulations to Ms. Mehar Un Nissa who has been awarded her doctorate degree at 60th Convocation of IIT Bombay. As a part of her PhD, she has developed a reference proteome and PTM map for Labeo rohita. This work has been selected for the front cover Proteome research. https://lnkd.in/dX8ycbyg
She has also worked on building the peptide repository “PeptideAtlas” for Labeo rohita which has been published in Nature Scientific Data. https://lnkd.in/dTcVU2JbWe have published one of the most comprehensive study on pituitary adenoma metabolomics using various analytical tools. Congratulations to Arghya Banerjee and all co-authors. Special thanks to Dr. Atul Goel, KEM hospital for all the support and clinical inputs. https://doi.org/10.1021/acs.analchem.2c02487Prof. Sanjeeva Srivastava’s lecture and visit of to the School of Biochemical Engineering, IIT BHU, on August 8, 2022.
JulyConducted Monsoon Advance Proteomics School (MAPS) 2022 workshop at IIT Bombay (July 18-29, 2022).
Meet our speakers (in pic)
https://lnkd.in/djMtq9nNLecture at Leibniz Institute for Analytical Sciences-ISAS Dortmund, Germany by Prof. Sanjeeva Srivastava from the Indian Institute of Technology, Bombay on the use of #proteomics-based assays- How can #COVID-19 be detected & prognosticated even in low viral load patients?Lecture by Prof. Srivastava at National University of Singapore (NUS). Special thanks to Prof Lin Qingsong for organizing the lecture.Here is an opportunity for students to attend one day Proteomics Capsule Course. https://www.youtube.com/watch?v=kX_ZtnZC80gThe Scientific Voyage (July - Sep 2022)!
Prof. Sanjeeva Srivastava's visits....a quest to enhance international collaborations and meet researchers and students from different parts of the globe!
https://www.youtube.com/watch?v=Q3nrEcp26Q4Publication of our book on "Multi-Pronged Omics Technologies to Understand COVID-19" by Taylor and Francis group. Thanks to all the co-authors for excellent contributions.
*Website is under maintenance
Dr. Sanjeeva Srivastava, FRSB, FRSC
Phone: +91-22-2576-7779 (office)
Dr. Sanjeeva Srivastava
Lab No: 304 (3rd Floor)
Department of Biosciences and Bioengineering, IIT-Bombay
Powai, Mumbai 400 076