Publications

• Khan AN, Chowdhury A, Karulkar A, Jaiswal AK, Banik A, Asija S, Purwar R*. Immunogenicity of CAR-T Cell Therapeutics: Evidence, Mechanism and Mitigation. Front Immunol. 2022, ^*Corresponding author

• Kumar S, Dhamija B, Attrish D, Sawant V, Sengar M, Thorat J, Shet T, Jain H, Purwar R.* Genetic alterations and oxidative stress in T cell lymphomas. Pharmacol Ther. 2022, ^*Corresponding author

• Das S, Surve V, Marathe M, Wad S, Karulkar A, Srinivasan S, Dwivedi A, Barthel SR, Purwar R^*. IL-9 abrogates the metastatic potential of breast cancer by controlling extracellular matrix remodeling and cellular contractility, The Journal of Immunology, 2021 in press, ^*Corresponding author

• Kumar S, Marathe S, Dhamija B, Zambare U, Bilala R, Warang S, Nayak C, Purwar R^*. Presence and the roles of IL-9/Th9 axis in Vitiligo. Pigment Cell and Melanoma Research, 2021 in press, ^*Corresponding author

• Marathe, S., Dhamija, B., Kumar, S., Jain, N., Ghosh, S., Prakash, J., Srinivasan, S., Das, S., Sawant, A., Desai, S., Khan, F., Syiemlieh, A., Munde, M., Nayak, C., Gandhi, M., Kumar, A., Srivastava, S., Venkatesh, K.V., Barthel, S.R.,  R^*. Multi-omics analysis and systems biology integration identifies the roles of IL-9 in keratinocyte metabolic reprogramming. Journal of Investigative Dermatology 2021 DOI: 10.1016/j.jid.2021.02.013, ^*Corresponding author

• Dwivedi, A., Karulkar, A., Ghosh, S., Srinivasan, S., Kumbhar, B.V., Jaiswal, A.K., Kizhakeyil, A., Asija, S., Rafiq, A., Kumar, S., Nisar, A., Patil, D.P., Poojary, M.V., Jain, H., Banavali, S.D., Highfill, S.L., Stroncek, D.F., Shah, N.N., Fry, T.J., Narula, G. and Purwar, R^*. Robust anti-tumor activity and low cytokine production by novel humanized anti-CD19 CAR-T cells. Molecular Cancer Therapeutics. 2021 DOI: 10.1158/1535-7163.MCT-20-0476, ^*Corresponding author

• A Verma, A Halder, S Marathe, R Purwar, S Srivastava. A proteogenomic approach to target neoantigens in solid tumors. Expert Review of Proteomics, 2020

• Kumar S, Dhamija B, Marathe S, Ghosh S, Dwivedi A, Karulkar A, Sharma N, Sengar M, Sridhar E, Bonda A, Thorat J, Tembhare P, Shet T, Gujral S, Bagal B, Laskar S, Jain H, Purwar R^*. The Th9 Axis Reduces the Oxidative Stress and Promotes the Survival of Malignant T Cells in Cutaneous T-Cell Lymphoma Patients. Molecular Cancer Research, 2020Apr;18(4):657-668. PubMed PMID: 31996468, ^*Corresponding author

• Srinivasan S, Das S, Surve V, Srivastava A, Kumar S, Jain N, Sawant A, Nayak C, Purwar R^*. Blockade of ROCK inhibits migration of human primary keratinocytes and malignant epithelial skin cells by regulating actomyosin contractility. Scientific Reports, 2019 Dec 27;9(1):19930. doi: 10.1038/s41598-019-56447-2, ^*Corresponding author

• Mogha P, Srivastava A, Kumar S, Das S, Kureel S, Dwivedi A, Karulkar A, Jain N, Sawant A, Nayak C, Majumder A^*, Purwar R^*. Hydrogel scaffold with substrate elasticity mimicking physiological-niche promotes proliferation of functional keratinocytes. RSC advance, 2019 Apr 2;9(18):10174-10183. This work was highlighted in “The Hindu” on April 6th 2019: Title “Now, culture more skin cells in less time”, ^*co-Corresponding author

• Das S, Srinivasan S, Srivastava A, Kumar S, Das G, Das S, Dwivedi A, Karulkar A, Makkad K, Bilala R, Gupta A, Sawant A, Nayak C, Tayalia P, Purwar R^*. Differential Influence of IL-9 and IL-17 on Actin Cytoskeleton Regulates the Migration Potential of Human Keratinocytes. The Journal of Immunology, 2019April 1;202(7):1949-1961, ^*Corresponding author

• Dwivedi A, Karulkar A, Ghosh S, Rafiq A, Purwar R*. Lymphocytes in Cellular Therapy: Functional Regulation of CAR T Cells. Frontiers in Immunology,2019, ^*Corresponding author

• Srinivasan S, Ashok V, Mohanty S, Das A, Das S, Kumar S, Sen S^*, Purwar R^*. Blockade of Rho-associated protein kinase (ROCK) inhibits the contractility and invasion potential of cancer stem like cells. Oncotarget. 2017Mar 28;8(13):21418-21428. This work was highlighted in The Hindu on 25th March 2017: Title “IIT Bombay researchers find a novel target for blocking cancer metastasis”, ^*Co-corresponding author

• Dwivedi A, Kumar S, Purwar R^*. B16 Lung Melanoma Model to Study the Role of Th9 Cells in Cancer. Methods Molecular Biology. 2017;1585:217-222. doi:10.1007/978-1-4939-6877-0_17. PubMed PMID: 28477199, ^*Corresponding author

• Purwar R, Schlapbach C,Xiao S, Kang HS, Elyaman W, Jetten AM, Khoury S, Fuhlbrigge RC, Kuchroo VK, Clark RA,Kupper TS: Robust tumor immunity to melanoma is mediated by IL‐9 producing T cells. Nat Med. 2012 Aug;18(8):1248-53 This work is appeared on numerous media websites around the globe including Fox news, NPR, Wall Street Journal, Zee news, Times of India, and The Hindu etc. (Impact factor 2012: 24.3)

• Purwar R^*, Bäumer W, Niebuhr M, Tschernig T, Kietzmann M, Werfel T. A protective role of complement component 3 in T cell‐mediated skin inflammation. Experimental Dermatology, 2011 Sep;20(9):709-14. ^*Corresponding author

• Purwar R, Campbell J, Murphy G, Richards WG, Clark RA, Kupper TS. Resident memory T cells (T(RM)) are abundant in human lung: diversity, function, and antigen specificity. PLoS One. 2011 Jan 26;6(1):e16245

• Purwar R^*, Langer K, Werfel T. Polymorphisms within the C3 gene are associated with specific IgE levels to common allergens and super antigens among atopic dermatitis patients. Experimental Dermatology, 2009 Jan;18(1):30-4. ^*Corresponding author

• Gschwandtner M, Purwar R, Wittmann M, Bäumer W, Kietzmann M, Werfel T, Gutzmer R. Histamine upregulates keratinocyte MMP‐9 production via the histamine H1 receptor. Journal of Investigative Dermatology, 2008 Dec;128(12):2783-91.

• Purwar R^*, Kraus M, Werfel T, Wittmann M. Modulation of keratinocyte‐derived MMP‐9 by IL-13: a possible role for the pathogenesis of epidermal inflammation. Journal of Investigative Dermatology, 2008 Jan;128(1):59-66. ^*Corresponding author

• Purwar R^*, Wittmann M, Zwirner J, Oppermann M, Kracht M, Dittrich‐Breiholz O,Gutzmer R, Werfel T. Induction of C3 and CCL2 by C3a in keratinocytes: a novel autocrine amplification loop of inflammatory skin reactions. The Journal of Immunology, 2006 Oct 1;177(7):4444-50, ^*Corresponding author

• Purwar R^*, Werfel T, Wittmann M. Regulation of IL‐13 receptors in human keratinocytes. Journal of Investigative Dermatology, 2007 May;127(5):1271-4.^*Corresponding author

• Gutzmer R, Köther B, Zwirner J, Dijkstra D, Purwar R, Wittmann M, Werfel T. Human plasmacytoid dendritic cells express receptors for anaphylatoxins C3a and C5a and are chemoattracted to C3a and C5a. Journal of Investigative Dermatology, 2006 Nov;126(11):2422-9

• Purwar R^*, Werfel T, Wittmann M. IL‐13‐stimulated human keratinocytes preferentially attract CD4+CCR4+ T cells: possible role in atopic dermatitis. Journal of Investigative Dermatology, 2006 May;126(5):1043-51. ^*Corresponding author

• Wittmann M, Purwar R, Hartmann C, Gutzmer R, Werfel T. Human keratinocytes respond to interleukin‐18: implication for the course of chronic inflammatory skin diseases. Journal of Investigative Dermatology, 2005 Jun;124(6):1225-33.