Courses

Course Name BB 411 Introduction to Molecular Cell Biology
Total Credits 6
Prerequisite BB101
Description
  1. Biochemical Unity and biological diversity - Chemical and Molecular Foundations (Molecules, Cells, Model Organisms, Molecules of Life, Pro/Eukaryotic cell structure, Microbial kingdom. Prokaryotes, eukaryotes, archaea. Microbial growth, Cells Build Supramolecular Structures, Model organisms, Separation techniques: basis and importance, Culturing and Visualising Cells, Growing cells in cultures, Microscopy – Light/Electron etc.
  2. Eukaryotic Cell cycle.
  3. The flow of genetic information - Central dogma, DNA, RNA, Protein, DNA replication, Transcription, and Translation.
  4. Chemical Building Blocks of Cells – Lipids/ membranes, Polysaccharides/Carbohydrates, Proteins, Amino acids, Proteins structure, Primary, Secondary, Tertiary, and Quaternary, Haemoglobin: portrait of an allosteric protein, Protein folding, Purifying, Detecting, characterising Proteins, and Proteomics)
  5. Enzymes - How Enzymes work, Mechanism and kinetics, Enzyme reactions – examples, Regulations
  6. Signal transduction - Extracellular cues to cellular response, Receptors/ GPCRs, Secondary messengers, signalling pathways – examples, Post-translational modifications and signalling.
  7. Protein trafficking - Protein targeting, Quality control, Vesicular traffic, secretion, and endocytosis
  8. Metabolism: basic concepts and design, Oxidative and photo-phosphorylation, Integration of metabolism, Cancers and metabolism.
  9. Recombinant DNA technology – Genomes, Concept of homology.
Course Name BB 628 - Molecular Cell Signaling – MSc and PhD Elective
Total Credits 6
Description
  1. Overview of cell-cell and intracellular signalling mechanisms, endocrine, paracrine, autocrine and synaptic transmissions.
  2. Cell-cell recognition, cell-adhesion molecules. Receptors (extracellular, intracellular), receptor-ligand interactions (agonist and antagonist), receptor characterizations, and receptor functions.
  3. Extracellular receptors: coupling of receptors to different signal transducing machinery; G-proteins, ion channels, and catalytic proteins. G-proteins: structure, function, adenylate cyclase system, cAMP-PK and CREB proteins. Calcium channels, oscillations of calcium conc. as signals.
  4. Receptors with protein tyrosine kinase activity, structure and function. Intracellular receptors: steroid receptors, structure and function. Second messengers: phosphoinositides, inositol 1,4,5 trisphosphate, diacylglycerol, cAMP, cGMP, arachidonic acid, prostaglandins, NO.
  5. Mechanisms of signal transduction: coupling of activation of receptors to intracellular signal transducing machinery, protein kinase cascades, gene regulation.
  6. Regulation of receptor function; receptor modifications; adaptation of cells. Signal transduction pathways in development and disease. Relationship of receptor tyrosine kinases with proto-oncogenes.
  7. Developmental abnormalities due to defective signalling pathways. Signal transducing machinery as targets for potential drugs