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Postdoctoral Fellows |
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Dr. Badgujar was in our group during October-2014 to December-2017. He performed structural studies to understand the molecular basis of pore formation by toxins. Dilip has determined crystal structure of an important toxin and performed detailed biophysical studies to unravel the mechanism of pore formation. He delivered a talk on his work in the 24th Congress & General Assembly of the International Union of Crystallography 2017. Curently Dilip is a senior scientist in Uppsala University, Sweden. Contact: dilip.bad@gmail.com |
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Dr. Dilip Badgujar |
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Dr. Kesari was in our group during April-2019 to March-2022. She primarily worked on structural studies of P. falciparum plasmepsin X (PMX). Research work by Pooja provided the first molecular isights into the inactivation mechanism of PMX zymogen. She has studied the molecular basis of substrate and inhibitor binding to PMX active site. She also performed bioinformatics and molecular dynamics (MD) simulation studies on several other proteins in my group. Pooja was involved in teaching Bioinformatics and MD siluation to the students. Pooja is currently working as a Rsearch Associate at Molecuar Biophysics Unit (MBU), IISc, Bangalore. Contact: pkesari88@gmail.com |
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Dr. Pooja Kesari |
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Dr. Pathan was in our group during April-2022 to November-2022. He performed molecular biology and biochemical studies on glutamate dehydrogenases (GDHs). He was actively involved in mentoring M.Sc. and Ph.D. students of our group. Curently Dr. Pathan is an Assistant Professor at Symbiosis International University, Pune. His group is studying morphogenesis in fungi to understand various biochemical/ molecular processes, and their possible applications. Contact: ejaj2185@gmail.com |
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Dr. Ejaj K. Pathan |
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Dr. Dasgupta was in our group during March-2022 to February-2024. He performed computational studies on mosquito D1-like dopamine receptors. He was actively involved in multiple collaborative projects and performed extensive MD simulation as well as QM/MM studies. He also mentored the Ph.D. students and extablished QM/MM expertise in our group. Curently Dr. Dasgupta is a postdoctoral fellow at RIKEN Center for Biosystems Dynamics Research, Japan. Contact: dasguptasubrata02@gmail.com |
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Dr. Subrata Dasgupta |
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Dr. Sairaman was in our group during September-2019 to June-2024. She developed artificial metalloenzyme based on structure based rational engineering. Anjali also worked on MD simulation studies of glutamate dehydrogenase (GDH). Anjali determined multiple high resolution crystal strctures of kinases. Contact: saianjali@gmail.com |
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Dr. Anjali Sairaman |
Ph.D. Students |
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Suman joined our group in July-2012. Her Ph.D. research porject was on understanding the structural basis of glucose transport mechanism in sugar transporters from Pseudomonas putida CSV86. She solved several high resolution structures of a glucose binding protein (ppGBP). She also purified and crystallized a membrane protein. Suman deciphered the mechanism of glucose transport through the membrane transporter. She received IUCr Travel Award. She defended her Ph.D. thesis in February-2018. Curently Dr. Pandey is a senior scientist at Mynvax Pvt. Ltd., Bangalore. Contact: sumanpandey0801@gmail.com |
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Dr. Suman Pandey |
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Prem was an intergrated M.Sc.-Ph.D. student. He joined our group in July-2012. His Ph.D. research porject was focused on understanding the catalytic mechanism and cofactor specificity of glutamate dehydrogenase (GDH). Prem determined svereal high resolution crystals structures of A. niger GDH (AnGDH). He managed to solve the structure of AnGDH complexed with its reaction intermediates in the active site. Prem's paper published in J. Biol. Chem. was featured on the cover page of the journal. Prem successfully defended his Ph.D. thesis in October-2018. Curently Dr. Prakash is a postdoctoral fellow at Meharry Medical College, USA. Contact: prem.prakash.iitb@gmail.com |
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Dr. Prem Prakash |
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Vandana primarily worked on structure based antimalarial drug development targeting vacuolar plasmepsins (PMs) from plasmodium parasites during her Ph.D. in our group. Vandana solved several high resolution crystal structures of P. falciparum PMII complexed with different KNI-inhibitors. She also determined crystal structures of PMII complexed with HIV-1 protease inhibitors which are FDA approved anti-HIV drugs. Dr. Mishra studied structural properties of non-vacuolar PMV as well. She delivered a talk on her work in the 24th Congress & General Assembly of the International Union of Crystallography 2017. Vandan defended her Ph.D. thesis in February-2020. Curently Dr. Mishra is a postdoctoral fellow at National Cancer Institute (NCI), NIH, USA. Contact: vandana.mishra021290@gmail.com |
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Dr. Vandana Mishra |
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As a Ph.D. student in our group, Ishan worked on understanding the activation mechanism of vacuolar plasmepsins (PMs). Ishan performed extensive crystallographic, biochemical and biophysial studies to decipher a novel activation mechanism of vacuolar plasmepsins (PMs). His studies have unraveled various new aspectes in understanding the catalytic mechanism of pepsin-like aspartic proteases and histo-aspartic protease (HAP). Dr. Rathore also solved multiple crystal structures of proteins other than plasmepsins. Ishan defended his Ph.D. theis in February-2021. Curently Dr. Rathore is a postdoctoral fellow at National Cancer Institute (NCI), NIH, USA. Contact: ishanrathore21@gmail.com |
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Dr. Ishan Rathore |
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Amrita worked on hydroxyatrazene degrading enzyme AtzB from P. putida. She performed extensive molecular dynamics (MD) simulation, mutagenesis and biochemical studies to understand the molecular basis of Zn-coordination, substrate recognition and catalytic mechanism of AtzB. Amrita has sucessfully defended her Ph.D. thesis in June-2022. Curently Dr. Sharma is a Research Scientist at Advanced Enzymes, Mumbai. Contact: amusharma213@gmail.com |
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Dr. Amrita Sharma |
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Barsa studied the molecular basis of inhibition and allosteric regulation in glutamate dehydrogenase (GDH). Barsa worked on the GDHs from Aspergillus niger, Aspergillus terreus and Saccharomyces cerevisiae. She performed extensive biochemical characterizations and determined multiple high resolution crystal structures to decipher the mechanism of inhibition of GDHs by dicarboxylic acid metabolites. Combining the structural and kinetics data, Barsa has demonstrated that the conformational dynamics and a remote network regulate the homotropic cooperativity in GDHs. Barsa has also determined cryo-EM structures of GDH to capture intrinsic dynamic nature of this enzyme. She delivered a lecture in the cryo-EM conference at IIT Bombay. She completed her Ph.D. degree in October-2023. Currently Dr. Godsora is a postdoctoral fellow at Uppsala University, Sweden. Contact: barsakanchan@gmail.com |
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Dr. Barsa Godsora |
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Anuradha worked on non-vacuolar plasmepsins (PMs) from P. falcipaum. Anuradha was involved in determination of the crystal structure of PMX zymogen which has prosegment with novel structural fold. She expressed PMIX and PMX as recombinant enzyme and performed assays to identify potential inhibitors against these proteases. Based on MD simulation studies, she identified the interactions responsible for the binding of the inhibitors in the active site of PMIX and PMX. Anuradha also demonstrated that some of the potent inhibitors of PMIX and PMX are capable of inhibiting the growth of malaria parasite. She performed research towards drug-repurposing to develop antimalrial drugs. Anuradha defended her Ph.D. thesis in October-2024. Currently Dr. Deshmukh is a postdoctoral fellow in Cancer Research Centre of Marseille (CRCM), France. Contact: anuradhadeshmukh907@gmail.com |
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Dr. Anuradha Deshmukh |
M.Sc./M.Tech. Students |
Ms. Sonam Srivastava |
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Sonam did her M.Sc. project in our group during 2023-2024. She graduated in May 2024. She performed expression, purification and modelling of a sugar transporter. Contact: sonamsrivastava432@gmail.com |
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Mr. Saswata Ganguly | Mr. Spandan Saha |
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Saswata did his M.Sc. project in our group during 2023-2024. He graduated in May 2024 and was awareded the Institute Silver Medal for academic excellence. He worked on omega transaminases. Currently he is a Ph.D. student at University of Heidelberg, Germany. Contact: saswatariju7@gmail.com |
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Spandan did his M.Sc. project in our group during 2023-2024. He graduated in May 2024. He performed structural, mutagenesis and biochemical studies on fungal glutamate dehydrogenase (GDH). Currently he is a Ph.D. student at Uppsala University, Sweden. Contact: spandansaha050601@gmail.com |
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Mr. Abhishek Rauniyar | Mr. Prasoon Kumar Mishra |
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Abhishek joined our group for his M. Tech. project. He was in our group during July 2022-June 2023. He worked on the developement of efficient cellulases for biofuel production. Currently he is working in a private company. Contact: abhishekrauniyar.iitb@gmail.com |
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Prasoon did his M.Sc. project in our group during 2022-2023. He graduated in May 2023. He performed structural and biochemical studies on glutamate dehydrogenase. Currently he is working at TATA Elxsi, Pune. Contact: prasoonkumardd@gmail.com |
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Md. Shabab Anwar | Mr. Rajiv Kumar |
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Shabab did his M.Sc. project in our group during 2022-2023. He graduated in May 2023. He worked on antiparasitic drug development targeting pepsin-like asprtic proteases from apicomplexan parasites. Currently he is working in a private company (Education sector). Contact: shabab.jnv@gmail.com |
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Rajiv joined our group for his M. Tech. project. He was in our group during July 2021-June 2022. He studied the structural dynamics of perforin like proteins from apicomplexan parasites. Currently he is working at CCTech. Contact: rajivkumar2505@gmail.com |
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Mr. Raghunath Singh | Ms. Pritha Dasgupta |
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Raghunath did his M.Sc. project in our group during 2021-2022. He graduated in May 2022. He worked on the structural studies on plasmepsin. Currently he is working at Bio Bharati Life Science, Kolkata. Contact: raghunath.singh1999@gmail.com |
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Pritha did her M.Sc. project in our group during 2020-2021. She graduated in May 2021. She worked on the structure based engineering of cellulases. Currently she is pursuing Ph.D. in MRC-PPU at University of Dundee. Contact: prithadasgupta74@gmail.com |
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Mr. Gajendra M. Singh | Mr. Nafizul Kazi |
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Gajendra joined our group for his M. Tech. project. He was in our group during July 2018-June 2019. He worked on the structural studies on pepsin-like aspartic proteases from T. Gondii. Currently he is working in a private company. Contact: gajendra.8454@gmail.com |
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Kazi did his M.Sc. project in our group during 2019-2020. He graduated in May 2020. He worked on the structural studies on plasmepsin. Currently he is pursuing Ph.D. in Max Planck Research School, Germany. Contact: nafizulhaquekazi@gmail.com |
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Mr. Nikhil Pahelkar | Ms. Tanya Joshi |
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Nikhil was in our group during July 2018 - May 2019 for his M.Sc. dissertation project. He worked on the structural studies on P. falciparum plasmepsins. Currently he is a PhD student at IISc Bangalore. Contact: pahelkar8@gmail.com |
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Tanya joined our group in October 2018. She graduated in May 2019. She worked on the structural studies on E. coli galactokinase. Currently she is pursuing Ph.D. in Heidelberg Bioscience International Graduate School, Germany. Contact: tanyajoshi7695@gmail.com |
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Mr. Deepak | Mr. Abhishek Balaji Suryawanshi |
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Deepak was in our group during July 2017 - May 2018. He worked on the structural studies on P. falciparum dihydropteroate synthase (DHPS). Currently he is a Ph.D. student at Institute of Biotechnology, Prague, the Czech Republic. Contact: deepmalik828@gmail.com |
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Abhishek joined our group in May 2017. He graduated in May 2018. He worked on the structural studies on P. falciparum Plasmepsin. Currently he is a Ph.D. student at the Dept. of Biosciences and Bioengineering at IIT Bombay. Contact: astikbalaji@gmail.com |
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Ms. Chandamita Saikia | Ms. Deepanwita Saha |
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Chhandamita worked on structural studies on plasmepsins from P. falciparum. She was in our group during May-2016 to July-2017. Currently she is a Ph.D. student at Weizmann Institute of Science, Israel. Contact: chandamitasaikia15@gmail.com |
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Deepanwita joined our group for her M.Sc. dissertation project during July-2016 to May-2017. She worked on a novel ATPase from S. pneumoniae. She is currently working in a pharmaceutical comapny as a scientist. Contact: deepanwita17@gmail.com |
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Mr. Pushpendu Mondal | Ms. Manisha Yadav |
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Puschpendu was in our group during July-2014 to May-2015. His M.Sc. dissertation project was focused on bioinformatic analysis of bacterial two component signal transduction systems. Currently he is an instructor in a teaching institution. Contact: pmon.0007@gmail.com |
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Manisha joined our group for her M.Sc. dissertation project during July-2014 to May-2015. She worked on a Histidine kinase (ComD) from S. pneumoniae. She is currently a Ph.D. student at Nanyang Technological University (NTU), Singapore. Contact: xxxxxxxx@xxx.xxxx |
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Ms. Aditi Jain | Ms. Avantika Singh |
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Aditi worked on galactokinase. She was in our group during July-2014 to May-2015. Currently she is a Ph.D. student at Indian Institute of Science, Bangalore, India. Contact: aditi2812jain@gmail.com |
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Avantika was in our group during July-2013 to May-2014. She worked on structural studies of Histo-aspartic Protease (HAP). She is currently a Ph.D. stuent at Institute of Microbial Technology (IMTech), Chandigarh. Contact: avantika_9876@yahoo.co.in |
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Ms. Pratibha Kumari | Ms. Anurag Kalia |
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Pratibha worked on structural studies on galactokinase. She was in our group during July-2013 to May-2014. Currently she is a Ph.D. student at IIT Indore. Contact: pratibhak1991@gmail.com |
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Anurag was in our group during July-2013 to May-2014. She worked on a structure guided modification of signal transducer for converting to a kinase. She is currently a Ph.D. student at National Institute of Immunology, New Delhi. Contact:xxxxxxxx@xxx.xxxx |
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Mr. Md. Saif | Ms. Sneha Soni |
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Saif worked on expression, purification and crystallization of Histo-aspartic protease (HAP) from P. falciparum. He was in our group during June-2012 to May-2013. Currently he is a Ph.D. student at Max-Delbrück-Centrum für Molekulare Medizin (MDC), Berlin, Germany. Contact: saif.biotech29@gmail.com |
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Sneha joined our group for her M.Sc. dissertation project during May-2012 to May-2013. She worked towards the conversion of a signal transducer into a catabolic enzyme. She is currently doing Ph.D. at IIT Varanasi. Contact: sneha.soni171@gmail.com |
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Project Staffs |
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Sweta joined our group in January-2013 and was here till July-2013. She worked on the expression and purification of (PMI) from P. falciparum. She also optimized expression conditions of other vacuolar plasmepsins. Contact: swetajhaveri@rocketmail.com |
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Ms. Sweta Jhaveri |
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Rajiv joined our group in October-2013 and was here till July-2017. Initially he worked on the modeling of plasmepsin V (PMV) from P. falciparum. He also performed virtual screening to find potential inhibitor of PMV for the development of antimalarial drugs. After the completion of his work on PMV, he performed extensive crystallographic studies on a beta-glucosidase. He determined several atomic resolution crystal structures of beta-glucosidase. Currently he is a postdoctoral-fellow at University of Zurich, Switzerland. Contact: rajivpsn@gmail.com |
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Mr. Rajiv K. Bedi |
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Tushar joined our group in June-2015 and was here till November-2016. He started working on refolding and purification of a membrane protein. He analyzied SAXS data to understand the oligomeric starte of a suger transporter. He also initiated the molecular dynamics simulation of the sugar transporter embedded in the membrane. He performed cloning, expression, purification and crystallization of a periplasmic sugar binding protein. Recently, he completed his Ph.D. from Centre for Free electron Laser Science (CFEL), Deutsches Elektronen-Synchrotron (DESY), Hamburg, Germany. Currently Tushar is a postdoctoral fellow at University of California, San Francisco. Contact: rtushar61@gmail.com |
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Mr. Tushar Rashkar |
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Anagha was a reserch project intern in our group during Jan-July, 2016. She joined our laboratory as a JRF in November-2016 and was here till October-2016. She has primarily worked on developing the assay to measure antimalarial activities of plasmepsin inhibitors. She is currently working as a scientist in a pharmaceutical company. Contact: anagha977@gmail.com |
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Ms. Anagha Arekar |
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Amrita joined our group in January-2017 and was here till July-2017. She has primarily worked on structure based improvement of cellulases. She is currently working as a scientist in a pharmaceutical company. Contact: amritaramesh0394@gmail.com |
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Ms. Amrita Ramesh |
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Meera joined our group in July-2017 and was here till July-2018. She has primarily worked on structure based improvement of cellulases. She is currently a Ph.D. student at IIT Bombay. Contact: meerapawar1994@gmail.com |
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Ms. Meera Pawar |
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Vaishnavi joined our group in July-2017 and was here till July-2018. She has primarily worked on structure based improvement of cellulases. She is currently a Ph.D. student at Boston College, USA. Contact: warriervaishnavi1@gmail.com |
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Ms. Vaishnavi Warrier |
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Aswathy joined our group in January-2018 and was here till July-2018. She has primarily worked on structure based antimalarial drug development project. She is currently working as a Research Associate at Jubilant Biosys Limited. Contact: aswathyp651@gmail.com |
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Ms. Aswathy Pillai |
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Jyoti joined our group in January-2019 and was here till July-2019. She has primarily worked on protein crystallographic studies and structure based antimalarial drug development project. She is currently working as a research scientist at BARC, Tarapur. Contact: simishrm1996@gmail.com |
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Ms. Jyoti K. Sharma |
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Shruti joined our group in January-2020. She has primarily worked on structure based antimalarial drug development project. Due to COVID-19 lockdown she worked from home from March-2020 and she completed her project by June-2020. Contact: shruti1752@gmail.com |
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Ms. Shruti Agrawal |
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Aishwarya joined our group in October-2021 and was here till May-2022. She has primarily worked on protein expression, purification and characterizations. She is currently working as a Jr. Executive (Regulatory Affairs) at Aarti Pharmalabs Ltd, Mumbai. Contact: aishwarya.sd03@gmail.com |
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Ms. Aishwarya Deshmukh |
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Dipayan was in our group for his M.Sc. disseration project during January-2024 to June-2024. Dipayan worked on rational engineering of a cellulase. He is currently a Ph.D. stuent at University of Würzburg, Germany. Contact: dipayanchatterjee53@gmail.com |
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Mr. Dipayan Chatterjee |
Short-term interns |
Ms. Manami Bhadra | Mr. Souvik Saha |
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Manami was in our group during summer 2015. She worked on bacterial two component system. Contact: bhadra.manami2493@gmail.com |
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Souvik joined our group for summer training during May-July, 2014. He worked on the structural studies on P. falciparum Plasmepsin. Contact: souvik.biospace@gmail.com |
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Ms. Christina Mathai | Ms. Sherin Ann Eapen |
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Christina was in our group during winter 2015. She worked on virtual screening of drug molecules. Currently she is doing her MS in Bioinformatics at Northeastern University, Boston, USA. Contact: chrisbijimathai@gmail.com |
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Sherin joined our group for a short term training projet during winter 2015. She worked on the structural bioinformatics. Currently she is pursuing M.Tech. in Bioinformatics from International Institute of Information Technology, Hyderabad. Contact: sherin1695@gmail.com |
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Ms. Anushka Chakraborty |
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Anushka was a medical student R.G. Kar Medical College, Kolkata. During her 3rd year of MBBS, she did a short term project in our group because of her interest in basic science. She worked on the structural studies on plasmepsins during her stay in our group during October 2018 - December 2018. Contact: anushkachakraborty1006@gmail.com |
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