“Uncovering the mysteries, solving real-world problems—it is cancer research”

Research

Diagram of IGF-1, EGF, TGF-β and IFN-γ signalling through receptors to Kelch, GrpE, ELMO and immunoglobulin superfamily proteins, driving proliferation, survival, migration and invasion — Breast Cancer Biology

Diagram of biological datasets feeding a machine learning model that predicts drug response, metastatic site and regulatory mutations — Computational Oncology

Diagram of a blood sample yielding circulating tumor DNA that is analysed by NGS and dPCR to detect tumor-derived alterations — ctDNA-Based Liquid Biopsy Assays

Flow diagram of MMR immunohistochemistry, MLH1 promoter methylation analysis and targeted molecular testing leading to targeted therapy and Lynch evaluation — MMR Deficiency in Endometrial Cancer & Lynch Syndrome Screening

Diagram of an inhibitor in the PI3Kα binding pocket beside the pipeline of docking, MD simulation, biochemical validation and synthesis of derivatives — Therapeutics – Development of PI3K-Alpha Mutant- and Isoform-Specific Inhibitor

Our laboratory utilizes computational and experimental approaches to model (computational modeling of the disease) and uncover unique dependencies of each subtype of breast cancer. Apart from fundamental biology, we try to translate science to solve real-world problems, such as developing liquid biopsy assays to detect cancer mutations in blood-derived tumor DNA, which may help in guiding the right treatment for a patient. Additionally, we have successfully developed novel small-molecule inhibitors for targeted therapies, with the aim of delivering less toxic, much lower-cost therapies.

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Welcome To The Precision Oncology Lab!

“Uncovering the mysteries, solving real-world problems—it is cancer research”

Research

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Team & Opportunities