2024
A B7-H4–Targeting Antibody–Drug Conjugate Shows Antitumor Activity in PARPi and Platinum-Resistant Cancers with B7-H4 Expression Sarah B Gitto, Margaret Whicker, Gareth Davies, Sushil Kumar, Krista Kinneer, Haineng Xu, Arthur Lewis, Srinivas Mamidi, Sergey Medvedev, Hyoung Kim, Judith Anderton, E Jessica Tang, Benjamin Ferman, Steven Coats, Robert W Wilkinson, Eric Brown, Daniel J Powell Jr, Fiona Simpkins (2024). Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-23-1079.
Bulky glycocalyx drives cancer invasiveness by modulating substrate-specific adhesion Sarah Barai, Amlan, Niyati Piplani, Sumon Kumar Saha, Sarbajeet Dutta, V. Gomathi, Mayank M. Ghogale, Sushil Kumar, Madhura Kulkarni, and Shamik Sen (2024). PNAS nexus. https://doi:10.1093/pnasnexus/pgae335.
2022
Tumor glycolysis, an essential sweet tooth of tumor cells. Sumana Paul, Saikat Ghosh, & Sushil Kumar (2022). In Seminars in Cancer Biology. Academic Press. https://doi.org/10.1016/j.semcancer.2022.09.007.
Publications Before Joining IIT Bombay
2021
Estrogen receptor β-mediated inhibition of actin-based cell migration suppresses metastasis of inflammatory breast cancer. Christoforos Thomas, Ilias V Karagounis, Ratnesh K Srivastava, Nicholas Vrettos, Fotis Nikolos, Noëlle Francois, Menggui Huang, Siliang Gong, Qi Long, Sushil Kumar, Constantinos Koumenis, Savitri Krishnamurthy, Naoto T Ueno, Rumela Chakrabarti, Amit Maity (2021). Cancer research, 81(9), 2399-2414. https://doi.org/10.1158/0008-5472.CAN-20-2743.
Dll1+ quiescent tumor stem cells drive chemoresistance in breast cancer through NF-κβ survival pathway. Sushil Kumar, Ajeya Nandi, Snahlata Singh, Rohan Regulapati, Ning Li, John W. Tobias, Christian W. Siebel, Mario Andres Blanco, Andres J. Klein-Szanto, Christopher Lengner, Alana L. Welm, Yibin Kang, and Rumela Chakrabarti (2021). Nature Communications. https://doi.org/10.1038/s41467-020-20664-5.
2020
Combining PARP with ATR inhibition overcomes PARP inhibitor and platinum resistance in ovarian cancer models. Hyoung Kim, Haineng Xu, Erin George, Dorothy Hallberg, Sushil Kumar, Veena Jagannathan, Sergey Medvedev, Yasuto Kinose, Kyle Devins, Priyanka Verma, Kevin Ly, Yifan Wang, Roger A. Greenberg, Lauren Schwartz, Neil Johnson, Robert B. Scharpf, Gordon B. Mills, Rugang Zhang, Victor E. Velculescu, Eric J. Brown & Fiona Simpkins (2020). Nature communications 11, no. 1: 1-16. https://doi.org/10.1038/s41467-020-17127-2.
Loss of ELF5–FBXW7 stabilizes IFNGR1 to promote the growth and metastasis of triple-negative breast cancer through interferon-γ signalling. Snahlata Singh, Sushil Kumar, Ratnesh Kumar Srivastava, Ajeya Nandi, Gatha Thacker, Hemma Murali, Sabrina Kim, Mary Baldeon, John Tobias, Mario Andres Blanco, Rizwan Saffie, M. Raza Zaidi, Satrajit Sinha, Luca Busino, Serge Y. Fuchs & Rumela Chakrabarti (2020). Nature cell biology 22, no. 5 (2020): 591-602. https://doi.org/10.1038/s41556-020-0495-y.
Inducible knockout of∆ Np63 alters cell polarity and metabolism during pubertal mammary gland development. Sushil Kumar, Ajeya Nandi, Aakash Mahesh, Satrajit Sinha, Elsa Flores, Rumela Chakrabarti (2020). FEBS letters 594, no. 6 (2020): 973-985. https://doi.org/10.1002/1873-3468.13703.
2019
Estrogen-dependent DLL1-mediated Notch signaling promotes luminal breast cancer. Sushil Kumar, Ratnesh Kumar Srivastav, David W Wilkes, Taylor Ross, Sabrina Kim, Jules Kowalski, Srinivas Chatla, Qing Zhang, Anupma Nayak, Manti Guha, Serge Y Fuchs, Christoforos Thomas, Rumela Chakrabarti (2019). Oncogene 38, no. 12: 2092-2107. https://doi.org/10.1038/s41388-018-0562-z.
2018
ΔNp63-driven recruitment of myeloid-derived suppressor cells promotes metastasis in triple-negative breast cancer. Sushil Kumar, David W Wilkes, Nina Samuel, Mario Andres Blanco, Anupma Nayak, Kevin Alicea-Torres, Christian Gluck, Satrajit Sinha, Dmitry Gabrilovich, Rumela Chakrabarti (2018). The Journal of clinical investigation 128, no. 11: 5095-5109. https://doi.org/10.1172/JCI99673.
MicroRNA hsa-miR-324-5p suppresses H5N1 virus replication by targeting the viral PB1 and host CUEDC2. Ashish Kumar, Akhilesh Kumar, Harshad Ingle, Sushil Kumar, Richa Mishra, Mahendra Kumar Verma, Debasis Biswas, Nachimuthu Senthil Kumar, Anamika Mishra, Ashwin Ashok Raut, Akinori Takaoka, Himanshu Kumar (2018). Journal of virology 92, no. 19: e01057-18. https://doi.org/10.1128/JVI.01057-18.
Notch ligand Dll1 mediates cross-talk between mammary stem cells and the macrophageal niche. Rumela Chakrabarti, Toni Celià-Terrassa, Sushil Kumar, Xiang Hang, Yong Wei, Abrar Choudhury, Julie Hwang, Jia Peng, Briana Nixon, John J Grady, Christina DeCoste, Jie Gao, Johan H van Es, Ming O Li, Iannis Aifantis, Hans Clevers, Yibin Kang (2018). Science 360, no. 6396: eaan4153. DOI: 10.1126/science.aan4153.