Better therapeutics and diagnosis of cancer may benefit millions of lives.
"Basic and applicable sciences are not different as fundamental discoveries pave way to cutting edge translational applications"
Our laboratory performs computational and wet lab analyses to identify driver genes and design novel targeted therapies. We are also engineering highly sensitive liquid biopsy assays for non-invasive early cancer detection.
Lab Updates
New Publications
Read our latest research papers and reviews.
Synthesis, structure and properties of Pt(II) α-pyrrolyl dipyrrin complexes that exhibit anticancer activities
Contributing Authors from Precision Oncology Lab: Sushil Kumar, Himanshu.
Summary
A series of Pt(II) α-pyrrolyl dipyrrin complexes was synthesized and characterized to investigate their structural, photophysical, and chemical properties. The novelty lies in the design of Pt(II)-dipyrrin architectures that combine distinctive coordination chemistry with biologically relevant properties. The complexes demonstrated anticancer activity, highlighting their potential as metal-based therapeutic candidates.
BPS2026 – Targeting the Skp1-Skp2 interaction interface with peptide-based inhibitor: Understanding the conformational implications of protein-peptide binding
Contributing Authors from Precision Oncology Lab: Sushil Kumar, Himanshu
Summary
The study uses a structure-guided approach to design peptides with defined conformational properties. These peptides were developed to modulate the protein–protein interaction and provide new molecular tools for studying SCF E3 ligase function.The work highlights a novel peptide-based strategy for targeting the Skp1–Skp2 interface.