Better therapeutics and diagnosis of cancer may benefit millions of lives.
On the therapeutics front, we try to answer fundamental questions of how cancer cells grow and metastasize using computational and wet lab approaches. Understanding these questions from molecular signaling standpoints helps us to design novel targeted therapies with better efficacy and less toxicity.
In diagnosis, the detection of cancer mutations may guide therapeutic intervention and lead to improved prognosis of patients. We try to develop a highly sensitive and accurate liquid biopsy assay for cancer detection. The assay may revolutionize disease management by predicting precise therapy regimes.
Lab Updates
Read our most recent article published in Seminars in Cancer Biology here
Cancer cells use glycolysis as the backbone of their metabolism to meet energy and building block demands. Aerobic glycolysis ferments glucose into lactate, supporting tumor growth and metastasis, which is accelerated by oncogenic signaling. The article focuses on tumor glycolysis and its interactions with other metabolic pathways, the role of key glycolytic enzymes in cancer, and the role of lactate in tumor growth and metastasis.