Welcome to Biomolecular NMR Spectroscopy lab.
The cellular processes in the human body and all other organisms are very complex and each event is intertwined with numerous other processes.
There are two ways to study these processes. One can either study the cascade of events as a whole to see how they affect the functioning of the cells, or the process can be broken down into its constituting molecules and each molecule studied individually in detail.
In the second approach, the properties of the molecules studied individually are then patched together to give an in-depth account of what happens in the cell. Proteins constitute the major component of these cascades in the cell and are required for all the basic functioning. To study these proteins individually requires the second approach. It is quite tedious and requires powerful tools that can examine atomic level details.
Our main work horse is Nuclear Magnetic Resonance (NMR) spectroscopy. We first illustrate the structure and dynamics of the molecule using NMR and this information is then combined with other biophysical tools and computational methods to decipher how two or more proteins will interact in the cell. For more details please check the Research