Minor Courses (Running In Spring Semester 2012 – 2013)
BM 600 : Introduction to BME (3-0-0-6)[Slot 5]
Prof. S. Mukherji [** also a Institute Elective]
General Introduction to Biomedical Engineering. Application of Engineering in Medicine. Electrical Potentials in the human body. Neuromuscular system: neurons, synapses and muscles, electrical properties of nerves and muscles, problems and diagnostics. Cardiovascular System: anatomy & physiology of the heart , ECG and the cardiac cycle, problems and solutions to electrical problems in the heart, blood and vascular modelling, haemodynamics, vascular diseases, catheterization, angiography & angioplasty, engineering in cardiovascular disease management. Skeletal System (including Prosthetics). Biomaterials and Implantable sensors, testing of Biomaterials – in vitro and in vivo. Excretory System (including Dialysis) : renal anatomy & physiology, the nephron, dialysis machines & mass transport. Medical Imaging : X-rays, design considerations of X-ray tubes, medical Image processing – projections, 3D-2D, slice identification, CAT, NMR, MRI, PET / SPECT. Cellular engineering and genetic engineering – introduction. Ethical considerations in Medical Research.
Text/References :
- J.T. Bushberg, J.A. Scibert, E.M. Leidholdt (Jr), J. M. Boone: The Essentials Physics of Medical Imaging, Lippincott Williams and Wilkins, USA, 2002.
- J. Enderle, S. Blanchard & J. Bronzino (Eds.): Introduction to Biomedical Engineering, Academic Press, 2000.
- John G. Webster (Ed.): Medical Instrumentation – Application and Design, 3rd Ed., John Wiley & Sons, 1998.
- J.B.West. (Ed.): Best and Taylor’s Physiological Basis of Medical Practice, 11th Ed., Williams and Wilkins, Baltimore, 1985.
- Y.C. Fung: Biomechanics, Springer-Verlag, New York, 1981.
- S. Oka: Cardiovascular Haemorheology, Cambridge University Press, 1981.
- R. Aston: Principles of Biomedical Instrumentation and Measurement, Merril Publishing Co., Columbus, 1990.
- W. Welkowitz, S. Deutsch & M. Akay: Biomedical Instruments – Theory and Design, 2nd Ed., Academic Press, San Diego CA, 1992.
- A. Macovski: Medical Imaging Systems, Prentice-Hall, Englewood Cliffs, 1983.
- R.D. Barr & R.L. Plonsey: Bioelectricity: A Quantitative Approach, Academic Press, N.Y., 1988.
- J.B. Park & R.S. Lakes: Biomaterials: An Introduction, Plenum Press, New York, 1992.
- D. L. Wise (Eds.): Encyclopedic Handbook of Biomaterials and Bioengineering (4 Vols.), Marcel Dekker, New York, 1995.
- R. William E. Russell: Medical imaging physics, 4th Ed, John Willey, USA, 2002.
BS 400 : Molecular Biophysics (2-1-0-6) [Slot 5]
Prof. S. Maji, A. Kumar
Molecular structure; Torsion angles; Steric effect: Contact distances; Homomorphous sugars; Cis & trans peptide bonds; Ramachandran map: for amino acids and as a general conformational analysis tool. Non-covalent interactions; hydrogen bond; stacking; Entropy: Entropy/enthalpy compensation; A=T vs. GºC. Effective conc. Enthalpic and entropic co-operativity. Oligopeptide conformation. Conformationally constrained amino acids; Hydrophobic effect; Affinity and specificity in intermolecular interactions; Stability of protein structure; Folding / unfolding; m values; Models of protein folding; Folding funnel; Contact order; F value analysis; Denatured state; Intrinsically unfolded proteins; Protein and RNA folding; In vivo folding; Kinetically stable proteins; Lipids: Assemblies; Volume, surface area, length relationship; X-ray studies; Phase transitions of anhydrous and hydrated lipid bilayers.
Text/References :
- Biophysical Chemistry, Vol. 1 & 3. C.R.Cantor and P.R.Schimmel; W.H. Freeman, 1980.
- Proteins. Structure and Molecular properties. T.Creighton. W.H.Freeman, 2nd ed. 1992.
- Protein structure. A practical approach. T.Creighton. Oxford Univ. Press. 2nd ed. 1997.
- The structure of biological membranes. P.L.Yeagle. CRC Press. 2nd ed. 2004.
BS 404 : Metabolism and Bioenergetics (2-1-0-6) [Slot 5]
Prof. S. Patankar
Overview of metabolism; concept of flow of matter and energy; thermodynamics of coupled systems and non-equilibrium reactions; biological energy currencies: high energy bond, reducing power and inter conversions of energy forms; carbon, nitrogen cycles in biosphere; classification of living system based on carbon and energy requirements; methods to study metabolism; carbohydrate and lipid catabolism; glycolysis; TCA cycle; fatty acid oxidation, other metabolic routes of carbon; oxidative phosphorylation; biosynthesis of carbohydrates and lipids photosynthesis; photosynthetic electron transport; Calvin cycle and other avenues of harvesting light energy; gluconeogenesis; Cori cycle; glycogen metabolism; biogenesis of fatty acids and sterols; nitrogen metabolism: sources of organic nitrogen; flow of nitrogen into biosynthesis and catabolism of amino acids; central role of glutamine; purines and pyrimidines; the metabolism of nucleotides; urea cycle and excretion of nitrogen; integration of metabolism and concepts of metabolic regulation.
Text/References :
- R.S. Ochs, R.W. Hanson and J. Halls; Metabolic Regulation. Elsevier, 1985.
- P.W. Atkins; Physical Chemistry. ELBS, 1981.
- J.G. Morris; A Biologist’s Physical Chemistry. 1974.
- Lehninger Principles of Biochemistry. D.L.Nelson and M.M.Cox. 4th ed. W.H.Freeman, 2004.
- Cellular physiology of nerves and muscles. G.G.Mathews. 4th ed. Blackwell Publishers, 2003
- Bioenergetics. D.G.Nicholls and S.J.Ferguson, 2nd ed. Academic Press, 2002.